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Abstract：
OBJECTIVE: To examine the effect of pregnancy history on the risk of stillbirth.
METHODS: In a population-based cross-sectional study, data were reviewed from all women aged at least 20 years with singleton pregnancies in Finland between 2000 and 2010. The primary outcome-stillbirth-was defined as fetal death after 22 gestational weeks or death of a fetus weighing at least 500 g.
RESULTS: Among 604 047 singleton pregnancies, the prevalence of stillbirth was 3.17 per 1000 deliveries. Prevalence was lowest for multiparous women without previous pregnancy loss after adjusting for major pregnancy complications associated with stillbirth (placenta previa, placental abruption, and pre-eclampsia) and other confounders. Relative to these women, stillbirth prevalence was higher among multiparous women with previous spontaneous abortion and/or stillbirth (adjusted odds ratio [aOR] 1.20, 95% confidence interval [CI] 1.05-1.36), nulliparous women with no previous pregnancy loss (aOR 1.23, 95% CI 1.10-1.38), and nulliparous women with prior spontaneous abortion (aOR 1.43, 95% CI 1.18-1.74).
CONCLUSIONS: Previous pregnancy loss was found to be an independent risk factor for stillbirth, irrespective of the number of prior deliveries.
METHODS: In a population-based cross-sectional study, data were reviewed from all women aged at least 20 years with singleton pregnancies in Finland between 2000 and 2010. The primary outcome-stillbirth-was defined as fetal death after 22 gestational weeks or death of a fetus weighing at least 500 g.
RESULTS: Among 604 047 singleton pregnancies, the prevalence of stillbirth was 3.17 per 1000 deliveries. Prevalence was lowest for multiparous women without previous pregnancy loss after adjusting for major pregnancy complications associated with stillbirth (placenta previa, placental abruption, and pre-eclampsia) and other confounders. Relative to these women, stillbirth prevalence was higher among multiparous women with previous spontaneous abortion and/or stillbirth (adjusted odds ratio [aOR] 1.20, 95% confidence interval [CI] 1.05-1.36), nulliparous women with no previous pregnancy loss (aOR 1.23, 95% CI 1.10-1.38), and nulliparous women with prior spontaneous abortion (aOR 1.43, 95% CI 1.18-1.74).
CONCLUSIONS: Previous pregnancy loss was found to be an independent risk factor for stillbirth, irrespective of the number of prior deliveries.
摘要：
目的：研究妊娠史对死产风险的影响。
方法：在一项基于人群的横断面研究中，我们回顾了2000年至2010年间芬兰所有20岁以上单胎妊娠女性的数据.主要结局-死产-定义为22孕周后的胎儿死亡或体重至少500g的胎儿死亡。
结果：在604.047例单胎妊娠中，死产的发生率为每1000例分娩3.17例.在调整与死产相关的主要妊娠并发症（前置胎盘，胎盘早剥,和先兆子痫)和其他混杂因素。相对于这些女人，在先前有自然流产和/或死产的经产妇女中，死产患病率较高（校正比值比[aOR]1.20，95%置信区间[CI]1.05-1.36），未妊娠妇女既往无妊娠损失（aOR1.23，95％CI1.10-1.38），和先前有自然流产的未产妇女（aOR1.43，95％CI1.18-1.74）。
结论：发现先前的妊娠丢失是死胎的独立危险因素，无论之前交付的数量如何。
方法：在一项基于人群的横断面研究中，我们回顾了2000年至2010年间芬兰所有20岁以上单胎妊娠女性的数据.主要结局-死产-定义为22孕周后的胎儿死亡或体重至少500g的胎儿死亡。
结果：在604.047例单胎妊娠中，死产的发生率为每1000例分娩3.17例.在调整与死产相关的主要妊娠并发症（前置胎盘，胎盘早剥,和先兆子痫)和其他混杂因素。相对于这些女人，在先前有自然流产和/或死产的经产妇女中，死产患病率较高（校正比值比[aOR]1.20，95%置信区间[CI]1.05-1.36），未妊娠妇女既往无妊娠损失（aOR1.23，95％CI1.10-1.38），和先前有自然流产的未产妇女（aOR1.43，95％CI1.18-1.74）。
结论：发现先前的妊娠丢失是死胎的独立危险因素，无论之前交付的数量如何。
