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Abstract：
OBJECTIVE: The study reports a 2-year single-center experience of the practice of skin antisepsis using a 0.05% sodium hypochlorite solution before central venous catheter placement in neonates.
METHODS: Eligible subjects included any hospitalized neonate who needed a central line for at least 48 hours. Infants were excluded if they had a generalized or localized skin disorder. An ad hoc Excel (Microsoft Corp, Redmond, WA) file was used to record the data from each patient. The catheter sites were monitored daily for the presence of contact dermatitis. Central line-associated bloodstream infection was diagnosed according to Centers for Disease Control and Prevention definition.
RESULTS: One hundred five infants underwent central venous catheter placement and were enrolled. A total of 198 central lines were inserted. The median gestational age was 31 weeks (range, 23-41 weeks) and median birth weight was 1,420 g (range, 500-5,170 g). There were no signs of 0.05% sodium hypochlorite-related skin toxicity in any infant. Of 198 catheters (1,652 catheter-days) prospectively studied, 9 were associated with bloodstream infections (5.4 per 1,000 catheter-days).
CONCLUSIONS: During the observation period, no local adverse effects were observed suggesting that 0.05% sodium hypochlorite may be a safe choice in this context.
METHODS: Eligible subjects included any hospitalized neonate who needed a central line for at least 48 hours. Infants were excluded if they had a generalized or localized skin disorder. An ad hoc Excel (Microsoft Corp, Redmond, WA) file was used to record the data from each patient. The catheter sites were monitored daily for the presence of contact dermatitis. Central line-associated bloodstream infection was diagnosed according to Centers for Disease Control and Prevention definition.
RESULTS: One hundred five infants underwent central venous catheter placement and were enrolled. A total of 198 central lines were inserted. The median gestational age was 31 weeks (range, 23-41 weeks) and median birth weight was 1,420 g (range, 500-5,170 g). There were no signs of 0.05% sodium hypochlorite-related skin toxicity in any infant. Of 198 catheters (1,652 catheter-days) prospectively studied, 9 were associated with bloodstream infections (5.4 per 1,000 catheter-days).
CONCLUSIONS: During the observation period, no local adverse effects were observed suggesting that 0.05% sodium hypochlorite may be a safe choice in this context.
摘要：
目的：该研究报告了新生儿中心静脉导管置入前使用0.05%次氯酸钠溶液进行皮肤防腐的2年单中心经验。
方法：符合条件的受试者包括任何住院新生儿，他们需要一个中心行至少48小时。如果婴儿患有全身或局部皮肤疾病，则将其排除在外。临时Excel(微软公司，雷德蒙德,WA)文件用于记录每位患者的数据。每天监测导管部位是否存在接触性皮炎。根据疾病控制和预防中心的定义，诊断出中心线相关的血流感染。
结果：105名婴儿接受了中心静脉置管，并被纳入研究。总共插入了198条中心线。中位胎龄为31周(范围，23-41周），中位出生体重为1,420g（范围，500-5,170克)。在任何婴儿中都没有0.05％次氯酸钠相关皮肤毒性的迹象。在前瞻性研究的198个导管（1,652个导管天）中，9例患者与血流感染相关（每1,000导管天5.4例）。
结论：在观察期间，未观察到局部不良反应,提示0.05%次氯酸钠可能是这种情况下的安全选择.
方法：符合条件的受试者包括任何住院新生儿，他们需要一个中心行至少48小时。如果婴儿患有全身或局部皮肤疾病，则将其排除在外。临时Excel(微软公司，雷德蒙德,WA)文件用于记录每位患者的数据。每天监测导管部位是否存在接触性皮炎。根据疾病控制和预防中心的定义，诊断出中心线相关的血流感染。
结果：105名婴儿接受了中心静脉置管，并被纳入研究。总共插入了198条中心线。中位胎龄为31周(范围，23-41周），中位出生体重为1,420g（范围，500-5,170克)。在任何婴儿中都没有0.05％次氯酸钠相关皮肤毒性的迹象。在前瞻性研究的198个导管（1,652个导管天）中，9例患者与血流感染相关（每1,000导管天5.4例）。
结论：在观察期间，未观察到局部不良反应,提示0.05%次氯酸钠可能是这种情况下的安全选择.
