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Abstract：
Variations within fat mass and obesity associated (FTO) gene had crosstalk with obesity risk in European and some Asian populations. This study was designed to investigate FTO rs9939609 association with metabolic syndrome (MetS) as well as biochemical parameters as plasma glucose, serum triacylglycerol (TAG), total cholesterol (TC) and transaminases enzymes in Arab female population from Egypt.
In order to achieve that, FTO gene rs9939609 (A < T) was genotyped using TaqMan SNP Genotyping Assay in a total of 197 females which were enrolled in this study. Fasting levels of serum insulin, lipid profile and plasma glucose, in addition to liver transaminases were measured. The association between the genotype distribution and MetS risk was evaluated using Chi-square and logistic regression tests in a case-control design under different genetic models.
The association of genotype distribution with MetS was significant (χ2 = 8.6/P = 0.014) with an increased odds ratio under dominant model (OR = 1.97, P = 0.029 and 95%C.I = 1.07-3.6) and recessive model (OR = 2.95, P = 0.017 and 95%C.I = 1.22-7.22). Moreover, (AA) subjects showed significant lower HDL-C levels (P = 0.009) when compared to (TT) ones. In addition, interestingly subjects with (AA) genotype have significantly higher ALT levels (P = 0.02) that remained significant after correction of major confounders as body mass index and serum triacylglycerols but not after conservative Bonferroni adjustment.
The present study shows for first time that FTO gene rs9939609 is genetic risk factor for metabolic syndrome in Egyptian population which may help in understanding the biology of this complex syndrome and highlighted that this association may be through HDL-C component. The association of this genetic polymorphism with ALT levels needs to be studied in other populations with larger sample size.
In order to achieve that, FTO gene rs9939609 (A < T) was genotyped using TaqMan SNP Genotyping Assay in a total of 197 females which were enrolled in this study. Fasting levels of serum insulin, lipid profile and plasma glucose, in addition to liver transaminases were measured. The association between the genotype distribution and MetS risk was evaluated using Chi-square and logistic regression tests in a case-control design under different genetic models.
The association of genotype distribution with MetS was significant (χ2 = 8.6/P = 0.014) with an increased odds ratio under dominant model (OR = 1.97, P = 0.029 and 95%C.I = 1.07-3.6) and recessive model (OR = 2.95, P = 0.017 and 95%C.I = 1.22-7.22). Moreover, (AA) subjects showed significant lower HDL-C levels (P = 0.009) when compared to (TT) ones. In addition, interestingly subjects with (AA) genotype have significantly higher ALT levels (P = 0.02) that remained significant after correction of major confounders as body mass index and serum triacylglycerols but not after conservative Bonferroni adjustment.
The present study shows for first time that FTO gene rs9939609 is genetic risk factor for metabolic syndrome in Egyptian population which may help in understanding the biology of this complex syndrome and highlighted that this association may be through HDL-C component. The association of this genetic polymorphism with ALT levels needs to be studied in other populations with larger sample size.
摘要：
在欧洲和一些亚洲人群中，脂肪量和肥胖相关（FTO）基因的变化与肥胖风险产生了串扰。这项研究旨在研究FTOrs9939609与代谢综合征（MetS）以及生化参数如血浆葡萄糖的相关性。血清三酰甘油（TAG），来自埃及的阿拉伯女性人口的总胆固醇（TC）和转氨酶。
为了实现这一目标，FTO基因rs9939609(A在显性模型下，基因型分布与MetS的相关性显着（χ2=8.6/P=0.014），比值比增加（OR=1.97，P=0.029和95％C。I=1.07-3.6）和隐性模型（OR=2.95，P=0.017和95％C。I=1.22-7.22)。此外，与（TT）相比，（AA）受试者的HDL-C水平显着降低（P=0.009）。此外,有趣的是，具有（AA）基因型的受试者的ALT水平显着升高（P=0.02），在校正了体重指数和血清三酰甘油等主要混杂因素后仍然显着，但在保守的Bonferroni调整后则没有。
本研究首次表明FTO基因rs9939609是埃及人群代谢综合征的遗传危险因素，这可能有助于理解这种复杂综合征的生物学特性，并强调这种关联可能是通过HDL-C成分。这种遗传多态性与ALT水平的关联需要在样本量较大的其他人群中进行研究。
为了实现这一目标，FTO基因rs9939609(A
本研究首次表明FTO基因rs9939609是埃及人群代谢综合征的遗传危险因素，这可能有助于理解这种复杂综合征的生物学特性，并强调这种关联可能是通过HDL-C成分。这种遗传多态性与ALT水平的关联需要在样本量较大的其他人群中进行研究。
