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Abstract：
Neuromuscular-blocking agents are commonly used in laboratory animal research settings. Due to actions of cholinergic receptors at locations other than the motor end-plate, these agents have a strong propensity to modulate autonomic outflow and may therefore not be desirable in studies examining autonomic function. This study aimed to compare the effect of two non-depolarizing neuromuscular-blocking agents, pancuronium and cisatracurium, on blood pressure, heart rate and non-invasive indices of autonomic function (heart rate variability, systolic blood pressure variability and baroreflex sensitivity) under two different types of anaesthesia in Lewis rats. Pancuronium produced a profound vagolytic response characterized by tachycardia, reduction in heart rate variability and baroreflex sensitivity under urethane anaesthesia, and with minimal effect under isoflurane anaesthesia. Conversely, cisatracurium produced no evidence of vagolytic action under either urethane or isoflurane anaesthesia. Therefore, for studies interested in examining autonomic function, particularly baroreflex or vagal function, neuromuscular blockade would be best achieved using cisatracurium.
摘要：
神经肌肉阻断剂通常用于实验动物研究环境。由于胆碱能受体在运动端板以外的位置的作用，这些药物有很强的调节自主神经流出的倾向,因此在检查自主神经功能的研究中可能并不理想.本研究旨在比较两种非去极化神经肌肉阻断剂的效果。潘库溴铵和顺式阿曲库铵，关于血压，心率和自主神经功能的非侵入性指标(心率变异性，Lewis大鼠在两种不同类型的麻醉下的收缩压变异性和压力反射敏感性）。潘库溴铵产生了以心动过速为特征的深刻的阴道溶解反应，尿烷麻醉下心率变异性和压力反射敏感性降低，在异氟烷麻醉下效果最小。相反，顺式阿曲库铵在氨基甲酸乙酯或异氟醚麻醉下都没有产生阴道溶解作用的证据。因此,对于有兴趣检查自主神经功能的研究，特别是压力反射或迷走神经功能，神经肌肉阻滞最好使用顺式阿曲库铵。
