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Abstract：
BACKGROUND: A clinical history of allergic symptoms and a skin-prick test with house-dust mite crude extracts are standard diagnostic procedures for Dermatophagoides pteronyssinus allergy. Specific immunoglobulin E (IgE) responses to Der p 1 and Der p 2 allergens have been used for the diagnosis of D. pteronyssinus allergy; however, evaluation of the diagnostic performance of Der p 1 and Der p 2 specific IgE (sIgE) produced inconsistent findings. We sought to evaluate the diagnostic accuracy of Der p 1 sIgE and Der p 2 sIgE measurement in the diagnosis of D. pteronyssinus allergy by performing a systematic review and meta-analysis of previously published studies.
METHODS: Several medical literature electronic data bases were searched for related literature published through August 1, 2016. A bivariate model was used to pool estimates of sensitivity, specificity, diagnostic odds ratio, and area under the summary receiver operating curves as the main diagnostic measures.
RESULTS: Eight studies, which involved 1095 patients, were included in our analysis. The pooled estimates of sensitivity, specificity, and diagnostic odds ratio for Der p 1 were 0.84, 0.97, and 166.57, respectively. The combined results for Der p 2 were a sensitivity of 0.87, specificity of 1.00, and a diagnostic odds ratio of 17342.35. The areas under the summary receiver operating curves for Der p 1 sIgE and Der p 2 sIgE were 0.94 and 0.98, respectively.
CONCLUSIONS: Our results supported the use of Der p 1 and Der p 2 sIgE in the diagnosis of D. pteronyssinus allergy. Both displayed good diagnostic performance and would be useful in a clinical setting in the accurate diagnosis of dust mite allergy.
METHODS: Several medical literature electronic data bases were searched for related literature published through August 1, 2016. A bivariate model was used to pool estimates of sensitivity, specificity, diagnostic odds ratio, and area under the summary receiver operating curves as the main diagnostic measures.
RESULTS: Eight studies, which involved 1095 patients, were included in our analysis. The pooled estimates of sensitivity, specificity, and diagnostic odds ratio for Der p 1 were 0.84, 0.97, and 166.57, respectively. The combined results for Der p 2 were a sensitivity of 0.87, specificity of 1.00, and a diagnostic odds ratio of 17342.35. The areas under the summary receiver operating curves for Der p 1 sIgE and Der p 2 sIgE were 0.94 and 0.98, respectively.
CONCLUSIONS: Our results supported the use of Der p 1 and Der p 2 sIgE in the diagnosis of D. pteronyssinus allergy. Both displayed good diagnostic performance and would be useful in a clinical setting in the accurate diagnosis of dust mite allergy.
摘要：
背景：过敏症状的临床病史和屋尘螨粗提物的皮肤点刺试验是翼状螨变态反应的标准诊断程序。对Derp1和Derp2变应原的特异性免疫球蛋白E(IgE)反应已被用于诊断翼状芽孢杆菌变态反应;然而,对Derp1和Derp2特异性IgE(sIgE)诊断性能的评估结果不一致.我们试图通过对先前发表的研究进行系统评价和荟萃分析来评估Derp1sIgE和Derp2sIgE测量在诊断翼状盘虫变态反应中的诊断准确性。
方法：检索截至2016年8月1日发表的相关文献。一个双变量模型被用来汇集灵敏度的估计，特异性，诊断赔率比，和汇总接受者工作曲线下的面积作为主要诊断措施。
结果：八项研究，涉及1095名患者，包括在我们的分析中。敏感性的汇总估计，特异性，Derp1的诊断比值比分别为0.84,0.97和166.57.Derp2的综合结果是灵敏度为0.87，特异性为1.00，诊断优势比为17342.35。Derp1sIgE和Derp2sIgE的总接受者工作曲线下面积分别为0.94和0.98。
结论：我们的结果支持使用Derp1和Derp2sIgE诊断翼龙球菌变态反应。两者都显示出良好的诊断性能，并且在临床环境中可以准确诊断尘螨过敏。
方法：检索截至2016年8月1日发表的相关文献。一个双变量模型被用来汇集灵敏度的估计，特异性，诊断赔率比，和汇总接受者工作曲线下的面积作为主要诊断措施。
结果：八项研究，涉及1095名患者，包括在我们的分析中。敏感性的汇总估计，特异性，Derp1的诊断比值比分别为0.84,0.97和166.57.Derp2的综合结果是灵敏度为0.87，特异性为1.00，诊断优势比为17342.35。Derp1sIgE和Derp2sIgE的总接受者工作曲线下面积分别为0.94和0.98。
结论：我们的结果支持使用Derp1和Derp2sIgE诊断翼龙球菌变态反应。两者都显示出良好的诊断性能，并且在临床环境中可以准确诊断尘螨过敏。
