METHODS: Several medical literature electronic data bases were searched for related literature published through August 1, 2016. A bivariate model was used to pool estimates of sensitivity, specificity, diagnostic odds ratio, and area under the summary receiver operating curves as the main diagnostic measures.
RESULTS: Eight studies, which involved 1095 patients, were included in our analysis. The pooled estimates of sensitivity, specificity, and diagnostic odds ratio for Der p 1 were 0.84, 0.97, and 166.57, respectively. The combined results for Der p 2 were a sensitivity of 0.87, specificity of 1.00, and a diagnostic odds ratio of 17342.35. The areas under the summary receiver operating curves for Der p 1 sIgE and Der p 2 sIgE were 0.94 and 0.98, respectively.
CONCLUSIONS: Our results supported the use of Der p 1 and Der p 2 sIgE in the diagnosis of D. pteronyssinus allergy. Both displayed good diagnostic performance and would be useful in a clinical setting in the accurate diagnosis of dust mite allergy.
方法:检索截至2016年8月1日发表的相关文献。一个双变量模型被用来汇集灵敏度的估计,特异性,诊断赔率比,和汇总接受者工作曲线下的面积作为主要诊断措施。
结果:八项研究,涉及1095名患者,包括在我们的分析中。敏感性的汇总估计,特异性,Derp1的诊断比值比分别为0.84,0.97和166.57.Derp2的综合结果是灵敏度为0.87,特异性为1.00,诊断优势比为17342.35。Derp1sIgE和Derp2sIgE的总接受者工作曲线下面积分别为0.94和0.98。
结论:我们的结果支持使用Derp1和Derp2sIgE诊断翼龙球菌变态反应。两者都显示出良好的诊断性能,并且在临床环境中可以准确诊断尘螨过敏。