关键词: IVIg intravenous immunoglobulin scleredema therapy treatment

Mesh : Adult Dermatologic Agents / therapeutic use Diabetes Complications / therapy Diabetes Mellitus, Type 1 / complications Disease Progression Female Humans Immunoglobulins, Intravenous / therapeutic use Scleredema Adultorum / etiology pathology therapy

来  源:   DOI:10.1111/dth.12504   PDF(Sci-hub)

Abstract:
Scleredema is a deposition disorder which presents as diffuse, symmetric, non-pitting skin induration from dermal deposits of glycosaminoglycans (\"mucins\"). It classically affects the upper back and posterior neck, often causing skin tightness and decreased range of motion. In most patients the clinical course is chronic and treatment options are limited. We report a case of a patient diagnosed with scleredema associated with longstanding insulin dependent diabetes who was treated successfully with IVIg. Additionally, we have reviewed the literature reporting other patients with scleredema treated with IVIg.
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