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Abstract：
Each year, more than 790 000 people in the United States suffer from a stroke. Although progress has been made in diagnosis and treatment of ischemic stroke (IS), new therapeutic interventions to protect the brain during an ischemic insult is highly needed. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression post-transcriptionally. Growing evidence suggests that miRNAs have a profound impact on ischemic stroke progression and are potential targets of novel treatments. Notably, inflammatory pathways play an important role in the pathogenesis of ischemic stroke and its pathophysiologic progression. Experimental and clinical studies have illustrated that inflammatory molecular events collaboratively contribute to neuronal and glial cell survival, edema formation and regression, and vascular integrity. In the present review, we examine recent discoveries regarding miRNAs and their roles in post-ischemic stroke neuropathogenesis.
摘要：
每一年,超过790.000人在美国患有中风。尽管在缺血性卒中（IS）的诊断和治疗方面取得了进展，非常需要在缺血性损伤期间保护大脑的新的治疗干预措施。microRNAs（miRNAs）很小，转录后调节基因表达的非编码RNA。越来越多的证据表明，miRNAs对缺血性卒中进展具有深远的影响，并且是新型治疗的潜在靶标。值得注意的是,炎症通路在缺血性卒中的发病机制及其病理生理过程中起重要作用。实验和临床研究表明，炎症分子事件共同促进神经元和神经胶质细胞存活，水肿的形成和消退，和血管完整性。在本次审查中，我们研究了最近发现的miRNAs及其在缺血性卒中后神经发病机制中的作用.
