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Abstract：
BACKGROUND: The regular update of the guidelines on fibromyalgia syndrome, AWMF number 145/004, was planned for April 2017.
METHODS: The guidelines were developed by 13 scientific societies and 2 patient self-help organizations coordinated by the German Pain Society. Working groups (n =8) with a total of 42 members were formed balanced with respect to gender, medical expertise, position in the medical or scientific hierarchy and potential conflicts of interest. A systematic search of the literature from December 2010 to May 2016 was performed in the Cochrane library, MEDLINE, PsycINFO and Scopus databases. Prospective population-based studies and systematic reviews with meta-analyses of case control studies were taken into consideration for the statements. Levels of evidence were assigned according to the classification system of the Oxford Centre for Evidence-Based Medicine version 2009. The statements were generated by multiple step formalized procedures. The guidelines were reviewed and approved by the board of directors of the societies engaged in the development of the guidelines.
RESULTS: Current data do not enable identification of distinct factors in the etiology and pathophysiology of fibromyalgia syndrome. Fibromyalgia syndrome can be associated with inflammatory rheumatic diseases, gene polymorphisms, life style factors (e.g. smoking, obesity and lack of physical activity), depressive disorders as well as physical and sexual abuse in childhood and adulthood.
CONCLUSIONS: Fibromyalgia syndrome is most probably the end result of various pathogenetic factors and pathophysiological mechanisms.
METHODS: The guidelines were developed by 13 scientific societies and 2 patient self-help organizations coordinated by the German Pain Society. Working groups (n =8) with a total of 42 members were formed balanced with respect to gender, medical expertise, position in the medical or scientific hierarchy and potential conflicts of interest. A systematic search of the literature from December 2010 to May 2016 was performed in the Cochrane library, MEDLINE, PsycINFO and Scopus databases. Prospective population-based studies and systematic reviews with meta-analyses of case control studies were taken into consideration for the statements. Levels of evidence were assigned according to the classification system of the Oxford Centre for Evidence-Based Medicine version 2009. The statements were generated by multiple step formalized procedures. The guidelines were reviewed and approved by the board of directors of the societies engaged in the development of the guidelines.
RESULTS: Current data do not enable identification of distinct factors in the etiology and pathophysiology of fibromyalgia syndrome. Fibromyalgia syndrome can be associated with inflammatory rheumatic diseases, gene polymorphisms, life style factors (e.g. smoking, obesity and lack of physical activity), depressive disorders as well as physical and sexual abuse in childhood and adulthood.
CONCLUSIONS: Fibromyalgia syndrome is most probably the end result of various pathogenetic factors and pathophysiological mechanisms.
摘要：
背景：纤维肌痛综合征指南的定期更新，AWMF编号145/004，计划于2017年4月。
方法：指南由13个科学学会和2个患者自助组织制定，由德国疼痛学会协调。由42名成员组成的工作组(n=8)在性别方面保持平衡，医学专家,在医学或科学等级制度中的地位和潜在的利益冲突。在Cochrane图书馆对2010年12月至2016年5月的文献进行了系统检索，MEDLINE,PsycINFO和Scopus数据库。这些陈述考虑了前瞻性基于人群的研究和病例对照研究荟萃分析的系统评价。根据牛津循证医学中心2009版的分类系统分配证据水平。语句是通过多步形式化程序生成的。这些准则由参与制定准则的协会的董事会审查和批准。
结果：目前的数据无法确定纤维肌痛综合征的病因和病理生理学中的不同因素。纤维肌痛综合征可与炎症性风湿性疾病相关，基因多态性，生活方式因素(例如吸烟，肥胖和缺乏体力活动)，抑郁症以及儿童和成年期的身体和性虐待。
结论：纤维肌痛综合征很可能是各种发病因素和病理生理机制的最终结果。
方法：指南由13个科学学会和2个患者自助组织制定，由德国疼痛学会协调。由42名成员组成的工作组(n=8)在性别方面保持平衡，医学专家,在医学或科学等级制度中的地位和潜在的利益冲突。在Cochrane图书馆对2010年12月至2016年5月的文献进行了系统检索，MEDLINE,PsycINFO和Scopus数据库。这些陈述考虑了前瞻性基于人群的研究和病例对照研究荟萃分析的系统评价。根据牛津循证医学中心2009版的分类系统分配证据水平。语句是通过多步形式化程序生成的。这些准则由参与制定准则的协会的董事会审查和批准。
结果：目前的数据无法确定纤维肌痛综合征的病因和病理生理学中的不同因素。纤维肌痛综合征可与炎症性风湿性疾病相关，基因多态性，生活方式因素(例如吸烟，肥胖和缺乏体力活动)，抑郁症以及儿童和成年期的身体和性虐待。
结论：纤维肌痛综合征很可能是各种发病因素和病理生理机制的最终结果。
