Cefiderocol MIC quality control ranges in iron-depleted cation-adjusted Mueller-Hinton broth using a CLSI M23-A4 multi-laboratory study design.

使用 CLSI M23 - A4 多实验室研究设计 ， 在贫铁阳离子调节的 Mueller - Hinton 肉汤中的头孢地洛 MIC 范围。

• 影响指数: 2.983
• 发表时间: Jun 2017
• 来源期刊: Diagn Microbiol Infect Dis
• DOI: 10.1016/j.diagmicrobio.2017.03.011
• PMID: 28410852
• 文章类型: Journal Article
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Huband MD,Ito A,Tsuji M,Sader HS,Fedler KA,Flamm RK

关键词: Cefiderocol; M23; Quality control; S-649266; Siderophore cephalosporin

Mesh: Anti-Bacterial Agents / pharmacology; Cephalosporins / pharmacology; Drug Resistance, Multiple, Bacterial; Escherichia coli / drug effects; Humans; Iron / metabolism; Microbial Sensitivity Tests / methods; Pseudomonas aeruginosa / drug effects; Quality Control; Cefiderocol

Abstract

Cefiderocol (formerly S-649266) is a new catechol-substituted parenteral siderophore cephalosporin with potent in vitro antibacterial activity against Gram-negative isolates including multidrug-resistant strains. A recent study following CLSI M23-A4 quality control guidelines established cefiderocol MIC QC ranges against Escherichia coli ATCC 25922 (0.06-0.5 μg/mL) and Pseudomonas aeruginosa ATCC 27853 (0.06-0.5 μg/mL).

摘要

头孢地洛（以前为S-649266）是一种新型的儿茶酚取代的肠胃外铁载体头孢菌素，对革兰氏阴性分离株包括多药耐药菌株具有有效的体外抗菌活性。根据CLSIM23-A4质量控制指南的最新研究建立了针对大肠杆菌ATCC25922（0.06-0.5μg/mL）和铜绿假单胞菌ATCC27853（0.06-0.5μg/mL）的头孢地洛MICQC范围。