关键词: Bacterial artificial chromosome Pseudorabies Recombination Vaccine platform

Mesh : Animals Chlorocebus aethiops Chromosomes, Artificial, Bacterial / genetics Genetic Vectors / genetics Herpesvirus 1, Suid / genetics immunology Humans Recombination, Genetic Vaccines, Synthetic / genetics immunology Vero Cells

来  源:   DOI:10.1007/978-1-4939-6869-5_5

Abstract:
Pseudorabies virus (PRV) is a promising vaccine vector due to its distinctive features including many nonessential replication regions and a broad host range. Foreign genes of other viruses have been successfully inserted into and expressed in PRV and these recombinant viruses are very likely to induce humoral and/or cellular responses in immunized animals. This chapter offers an overview of methods for generating recombinant pseudorabies virus for use as a vaccine vector.
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