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Abstract：
OBJECTIVE: To investigate the ultrasound (US) markers predictive of complex gastroschisis (CG), mortality, and morbidity in fetuses with gastroschisis.
METHODS: This was a retrospective cohort study of 186 pregnancies with isolated fetal gastroschisis. Eight US markers were analyzed. The predictions and associations of US markers with CG, mortality, and morbidity were assessed. Combinations of US markers predictive of CG were investigated.
RESULTS: Extra-abdominal bowel dilatation (EABD), intra-abdominal bowel dilatation (IABD), and polyhydramnios were predictive of CG. EABD between 25 and 28 weeks had a sensitivity of 64%, a specificity of 89%, a positive predictive value (PPV) of 56.2%, and negative predictive value (NPV) of 91.8%. The predictions of IABD were sensitivity = 26.7%, specificity = 96.7%, PPV = 61.5%, and NPV = 86.8%. The odds ratios for CG in the presence of 1 and 2 US markers, compared with the absence of a US marker, were 18.3 (95% CI, 3.83-87.64) and 73.3 (95% CI, 6.14-876), respectively.
CONCLUSIONS: US markers predictive of CG were established. The combination of these markers increases the probability of CG.
METHODS: This was a retrospective cohort study of 186 pregnancies with isolated fetal gastroschisis. Eight US markers were analyzed. The predictions and associations of US markers with CG, mortality, and morbidity were assessed. Combinations of US markers predictive of CG were investigated.
RESULTS: Extra-abdominal bowel dilatation (EABD), intra-abdominal bowel dilatation (IABD), and polyhydramnios were predictive of CG. EABD between 25 and 28 weeks had a sensitivity of 64%, a specificity of 89%, a positive predictive value (PPV) of 56.2%, and negative predictive value (NPV) of 91.8%. The predictions of IABD were sensitivity = 26.7%, specificity = 96.7%, PPV = 61.5%, and NPV = 86.8%. The odds ratios for CG in the presence of 1 and 2 US markers, compared with the absence of a US marker, were 18.3 (95% CI, 3.83-87.64) and 73.3 (95% CI, 6.14-876), respectively.
CONCLUSIONS: US markers predictive of CG were established. The combination of these markers increases the probability of CG.
摘要：
目的：为了研究超声（US）标志物对复杂腹裂（CG）的预测，死亡率,以及腹裂胎儿的发病率。
方法：这是一项回顾性队列研究，共进行了186例妊娠孤立性胎儿腹裂。分析了八个美国标记。美国标记与CG的预测和关联，死亡率,和发病率进行了评估。研究了预测CG的US标志物的组合。
结果：腹外肠扩张（EABD），腹内肠扩张（IABD），羊水过多是CG的预测因素。EABD在25至28周之间的敏感性为64％，特异性为89%，阳性预测值(PPV)为56.2%，阴性预测值(NPV)为91.8%。IABD的预测灵敏度为26.7%，特异性=96.7%，PPV=61.5%,净现值=86.8%。在存在1个和2个US标记的情况下，CG的优势比，与没有美国标记相比，分别为18.3(95%CI，3.83-87.64)和73.3(95%CI，6.14-876)，分别。
结论：建立了预测CG的US标志物。这些标记的组合增加了CG的概率。
方法：这是一项回顾性队列研究，共进行了186例妊娠孤立性胎儿腹裂。分析了八个美国标记。美国标记与CG的预测和关联，死亡率,和发病率进行了评估。研究了预测CG的US标志物的组合。
结果：腹外肠扩张（EABD），腹内肠扩张（IABD），羊水过多是CG的预测因素。EABD在25至28周之间的敏感性为64％，特异性为89%，阳性预测值(PPV)为56.2%，阴性预测值(NPV)为91.8%。IABD的预测灵敏度为26.7%，特异性=96.7%，PPV=61.5%,净现值=86.8%。在存在1个和2个US标记的情况下，CG的优势比，与没有美国标记相比，分别为18.3(95%CI，3.83-87.64)和73.3(95%CI，6.14-876)，分别。
结论：建立了预测CG的US标志物。这些标记的组合增加了CG的概率。
