Abstract：
The regulation of the expression of the operons in the flagella-chemotaxis regulon in Escherichia coli has been shown to be a highly ordered cascade which closely parallels the assembly of the flagellar structure and the chemotaxis machinery (T. Iino, Annu. Rev. Genet. 11:161-182, 1977; Y. Komeda, J. Bacteriol. 168: 1315-1318). The master operon, flbB, has been sequenced, and one of its gene products (FlaI) has been identified. On the basis of the deduced amino acid sequence, the FlbB protein has similarity to an alternate sigma factor which is responsible for expression of flagella in Bacillus subtilis. In addition, we have sequenced the 5\' regions of a number of flagellar operons and compared these sequences with the 5\' region of flagellar operons directly and indirectly under FlbB and FlaI control. We found both a consensus sequence which has been shown to be in all other flagellar operons (J. D. Helmann and M. J. Chamberlin, Proc. Natl. Acad. Sci. USA 84:6422-6424) and a derivative consensus sequence, which is found only in the 5\' region of operons directly under FlbB and FlaI control.
摘要：
大肠杆菌鞭毛趋化调节子中操纵子表达的调节已被证明是高度有序的级联反应，与鞭毛结构和趋化机制的组装密切相关（T。伊诺,安努。Rev.Genet.11：161-182，1977；Y.Komeda，J、细菌醇。168：1315-1318）。主操纵子，flbB,已经测序了，它的一个基因产物（FlaI）已经被鉴定出来。根据推导的氨基酸序列，FlbB蛋白与负责枯草芽孢杆菌中鞭毛表达的交替σ因子具有相似性。此外,我们已经对许多鞭毛操纵子的5个区域进行了测序，并将这些序列与直接和间接在FlbB和FlaI控制下的鞭毛操纵子的5个区域进行了比较。我们发现这两个共有序列已被证明在所有其他鞭毛操纵子中（J.D.Helmann和M.J.Chamberlin,Proc.纳特.Acad.Sci.美国84：6422-6424）和衍生的共有序列，仅在FlbB和FlaI控制下的5个操纵子区域中发现。
