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Abstract：
Hypertension and chronic kidney disease (CKD) have a significant impact on global morbidity and mortality. The Low Birth Weight and Nephron Number Working Group has prepared a consensus document aimed to address the relatively neglected issue for the developmental programming of hypertension and CKD. It emerged from a workshop held on April 2, 2016, including eminent internationally recognized experts in the field of obstetrics, neonatology, and nephrology. Through multidisciplinary engagement, the goal of the workshop was to highlight the association between fetal and childhood development and an increased risk of adult diseases, focusing on hypertension and CKD, and to suggest possible practical solutions for the future. The recommendations for action of the consensus workshop are the results of combined clinical experience, shared research expertise, and a review of the literature. They highlight the need to act early to prevent CKD and other related noncommunicable diseases later in life by reducing low birth weight, small for gestational age, prematurity, and low nephron numbers at birth through coordinated interventions. Meeting the current unmet needs would help to define the most cost-effective strategies and to optimize interventions to limit or interrupt the developmental programming cycle of CKD later in life, especially in the poorest part of the world.
摘要：
高血压和慢性肾脏病(CKD)对全球发病率和死亡率有显著影响。低出生体重和肾单位数量工作组已经准备了一份共识文件，旨在解决高血压和CKD发育规划中相对被忽视的问题。它来自于2016年4月2日举行的研讨会，包括产科领域的国际知名专家，新生儿科,和肾病学。通过多学科参与，研讨会的目的是强调胎儿和儿童发育与成人疾病风险增加之间的关系，关注高血压和CKD，并为未来提出可行的解决方案。共识研讨会的行动建议是结合临床经验的结果，分享研究专业知识，和文献综述。他们强调需要及早采取行动，通过减少低出生体重来预防CKD和其他相关的非传染性疾病。小于胎龄，早产,通过协调干预，出生时的肾单位数量较低。满足当前未满足的需求将有助于确定最具成本效益的战略，并优化干预措施，以限制或中断CKD在以后生活中的发展规划周期。尤其是世界上最贫穷的地方.
