关键词： antipsychotics neurexin-1 (NRXN1) pharmacogenetic schizophrenia (SCZ) tardive dyskinesia (TD)

Mesh ： Adult Antipsychotic Agents / adverse effects Calcium-Binding Proteins Cell Adhesion Molecules, Neuronal / genetics Female Genetic Association Studies / methods Humans Male Nerve Tissue Proteins / genetics Neural Cell Adhesion Molecules Polymorphism, Single Nucleotide / genetics Schizophrenia / drug therapy genetics Tardive Dyskinesia / chemically induced genetics Whites / genetics

来  源：   DOI：10.1002/hup.2568   PDF(Sci-hub)

Abstract：
Tardive dyskinesia (TD) is a motor side effect that may develop after long-term antipsychotic treatment. Schizophrenia has recently been associated with the Neurexin-1 (NRXN1) gene that codes for a cell adhesion molecule in synaptic communication.
This study examined five NRXN1 single-nucleotide polymorphisms (SNPs) for possible association with the occurrence and severity of TD in 178 schizophrenia patients of European ancestry.
We did not find these SNPs to be significantly associated with TD.
More research is needed with additional SNPs and in bigger samples before we can completely rule out the role of NRXN1 in TD.
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