{Reference Type}: Journal Article
{Title}: Association study between the neurexin-1 gene and tardive dyskinesia.
{Author}: Lanning R;Lett TA;Tiwari AK;Brandl EJ;de Luca V;Voineskos AN;Potkin SG;Lieberman JA;Meltzer HY;Müller DJ;Remington G;Kennedy JL;Zai CC;
{Journal}: Hum Psychopharmacol
{Volume}: 32
{Issue}: 1
{Year}: 01 2017
{Factor}: 2.13
{DOI}: 10.1002/hup.2568
{Abstract}: Tardive dyskinesia (TD) is a motor side effect that may develop after long-term antipsychotic treatment. Schizophrenia has recently been associated with the Neurexin-1 (NRXN1) gene that codes for a cell adhesion molecule in synaptic communication.<BR>This study examined five NRXN1 single-nucleotide polymorphisms (SNPs) for possible association with the occurrence and severity of TD in 178 schizophrenia patients of European ancestry.<BR>We did not find these SNPs to be significantly associated with TD.<BR>More research is needed with additional SNPs and in bigger samples before we can completely rule out the role of NRXN1 in TD.