预测标志物指导分化以改善基于 hESC 的帕金森病治疗的临床翻译中的移植物结果。
关键词: FGF8 GMP MHB Parkinson’s disease STN VM diencephalon dopaminergic neurons good manufacturing practice hESCs human embryonic stem cells midbrain-hindbrain boundary subthalamic nucleus transplantation ventral midbrain
Mesh : Animals Biomarkers / metabolism Cell Differentiation / drug effects Cell Lineage / drug effects Cells, Cultured Dopamine / metabolism Dopaminergic Neurons / cytology drug effects metabolism Extracellular Matrix / drug effects metabolism Female Fibroblast Growth Factor 8 / metabolism Human Embryonic Stem Cells / cytology drug effects transplantation Humans Laminin / pharmacology Mesencephalon / metabolism Parkinson Disease / therapy Rats, Sprague-Dawley Reproducibility of Results Sequence Analysis, RNA Stem Cell Transplantation Subthalamic Nucleus / cytology metabolism Time Factors Translational Research, Biomedical Treatment Outcome
来 源:
DOI:10.1016/j.stem.2016.09.004
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