Abstract：
The present study investigated the impact of a western diet during gestation and lactation on the anthropometry, serum biochemical, blood pressure and cardiovascular autonomic control on the offspring. Male Wistar rats were divided into two groups according to their mother\'s diet received: control group (C: 18% calories of lipids) and westernized group (W: 32% calories of lipids). After weaning both groups received standard diet. On the 60th day of life, blood samples were collected for the analysis of fasting glucose and lipidogram. Cardiovascular parameters were measured on the same period. Autonomic nervous system modulation was evaluated by spectrum analysis of heart rate (HR) and systolic arterial pressure (SAP). The W increased glycemia (123±2 v. 155±2 mg/dl), low-density lipoprotein (15±1 v. 31±2 mg/dl), triglycerides (49±1 v. 85±2 mg/dl), total cholesterol (75±2 v. 86±2 mg/dl), and decreased high-density lipoprotein (50±4 v. 38±3 mg/dl), as well as increased body mass (209±4 v. 229±6 g) than C. Furthermore, the W showed higher SAP (130±4 v. 157±2 mmHg), HR (357±10 v. 428±14 bpm), sympathetic modulation to vessels (2.3±0.56 v. 6±0.84 mmHg2) and LF/HF ratio (0.15±0.01 v. 0.7±0.2) than C. These findings suggest that a western diet during pregnancy and lactation leads to overweight associated with autonomic misbalance and hypertension in adulthood.
摘要：
本研究调查了妊娠和哺乳期西方饮食对人体测量学的影响，血清生化，血压和心血管自主神经控制对后代的影响。雄性Wistar大鼠根据其母亲接受的饮食分为两组：对照组（C：18％卡路里的脂质）和西化组（W：32％卡路里的脂质）。断奶后，两组均接受标准饮食。在生命的第60天，收集血液样本进行空腹血糖和血脂图分析.在同一时期测量心血管参数。通过心率（HR）和收缩压（SAP）的频谱分析评估自主神经系统的调节。W增加血糖（123±2v.155±2mg/dl），低密度脂蛋白（15±1v.31±2mg/dl），甘油三酯（49±1v.85±2mg/dl），总胆固醇（75±2v.86±2mg/dl），并降低高密度脂蛋白（50±4v.38±3mg/dl），以及比C增加的体重（209±4v.229±6g）。此外，W显示较高的SAP（130±4v.157±2mmHg），HR(357±10v.428±14bpm)，与C相比，对血管的交感神经调节（2.3±0.56v.6±0.84mmHg2）和LF/HF比率（0.15±0.01v.0.7±0.2）。这些发现表明，怀孕和哺乳期间的西方饮食会导致超重，与成年期的自主神经失衡和高血压有关。
