关键词： Lacazia loboi P. lutzii Paracoccidioides brasiliensis Tursiops truncatus bottlenose dolphins cutaneous granulomas dolphins fungi lacaziosis lobomycosis paracoccidioidomycosis paracoccidioidomycosis ceti phylogenetic analysis

Mesh ： Animal Diseases / microbiology pathology Animals Base Sequence Biopsy DNA, Fungal Dermatomycoses / veterinary Dolphins Granuloma / veterinary Paracoccidioides / classification genetics isolation & purification Paracoccidioidomycosis / veterinary Phylogeny

来  源：   DOI：10.3201/eid2212.160860   PDF(Sci-hub)

Abstract：
Cutaneous granulomas in dolphins were believed to be caused by Lacazia loboi, which also causes a similar disease in humans. This hypothesis was recently challenged by reports that fungal DNA sequences from dolphins grouped this pathogen with Paracoccidioides brasiliensis. We conducted phylogenetic analysis of fungi from 6 bottlenose dolphins (Tursiops truncatus) with cutaneous granulomas and chains of yeast cells in infected tissues. Kex gene sequences of P. brasiliensis from dolphins showed 100% homology with sequences from cultivated P. brasiliensis, 73% with those of L. loboi, and 93% with those of P. lutzii. Parsimony analysis placed DNA sequences from dolphins within a cluster with human P. brasiliensis strains. This cluster was the sister taxon to P. lutzii and L. loboi. Our molecular data support previous findings and suggest that a novel uncultivated strain of P. brasiliensis restricted to cutaneous lesions in dolphins is probably the cause of lacaziosis/lobomycosis, herein referred to as paracoccidioidomycosis ceti.
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