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Abstract：
The number of studies in cell biology in which quantitative models accompany experiments has been growing steadily. Roughly, mathematical and computational techniques of these models can be classified as \"differential equation based\" (DE) or \"agent based\" (AB). Recently AB models have started to outnumber DE models, but understanding of AB philosophy and methodology is much less widespread than familiarity with DE techniques. Here we use the history of modeling a fundamental biological problem-positioning of the cleavage furrow in dividing cells-to explain how and why DE and AB models are used. We discuss differences, advantages, and shortcomings of these two approaches.
摘要：
在细胞生物学中，定量模型伴随实验的研究数量一直在稳步增长。粗略地,这些模型的数学和计算技术可以分为“基于微分方程”（DE）或“基于代理”（AB）。最近AB型号开始超过DE型号，但是对AB哲学和方法论的理解远不及对DE技术的熟悉。在这里，我们使用对基本生物学问题建模的历史-分裂细胞中卵裂沟的定位-来解释如何以及为什么使用DE和AB模型。我们讨论分歧，优势,以及这两种方法的缺点。
