PDF(Pubmed)
Abstract：
Matrix metalloproteinase-9 (MMP-9) is an inducible enzyme. Oral potentially malignant disorders (OPMDs) are considered as the early tissue changes that happen due to various habits such as smoking tobacco, chewing tobacco or stress. This alteration in the tissues alters the expression of MMP-9. The rationale of the review is to know the expression of MMP-9 in OPMDs. Hand searching and electronic databases such as PubMed and ScienceDirect were done for mesh terms such as OPMDs and MMP-9. Eight articles were obtained, after applying inclusion and exclusion criteria. These articles were assessed with QUADAS and data were extracted and evaluated. The included eight studies were done in 182 oral squamous cell carcinoma cases, 430 OPMDs (146 oral lichen planus, 264 leukoplakia and 20 oral submucous fibrosis) and 352 healthy controls evaluated for MMP-9. MMP-9 expression was found to be elevated in tissue, serum and saliva samples of OPMDs than in healthy controls. There is only one study in each serum and saliva samples to evaluate MMP-9. Saliva being noninvasive and serum being minimally invasive, more studies need to be done in both serum and saliva to establish MMP-9 as an early diagnostic marker in OPMDs to know its potential in malignant transformation.
摘要：
基质金属蛋白酶-9(MMP-9)是一种诱导酶。口腔潜在恶性疾病（OPMD）被认为是由于吸烟等各种习惯而发生的早期组织变化，咀嚼烟草或压力。组织中的这种改变改变了MMP-9的表达。该综述的基本原理是了解MMP-9在OPMDs中的表达。对OPMD和MMP-9等网格术语进行了手工搜索和电子数据库如PubMed和ScienceDirect。获得了八篇文章，在应用纳入和排除标准后。使用QUADAS对这些文章进行评估，并提取和评估数据。纳入的八项研究是在182例口腔鳞状细胞癌病例中进行的，430OPMD（146口腔扁平苔藓，264个白斑和20个口腔粘膜下纤维化）和352个健康对照者评估了MMP-9。发现MMP-9在组织中表达升高，OPMDs的血清和唾液样本比健康对照。在每种血清和唾液样品中只有一项研究来评估MMP-9。唾液是非侵入性的，血清是微创的，需要在血清和唾液中进行更多的研究，以确定MMP-9作为OPMDs的早期诊断标志物，以了解其在恶性转化中的潜力。
