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Abstract：
BACKGROUND: Photosensitivity to Chlamydia trachomatis has been described in almost 50% of chronic cases of lymphogranuloma venereum (LGV) caused by L1, L2 or L3 serovars. Photosensitivity in non LGV strains of C trachomatis has not been studied. We studied the association of various photosensitive dermatoses with C trachomatis infection in non LGV cases.
METHODS: Sera of all the cases of photosensitivity, melasma, chronic actinic dermatitis (CAD), polymorphic light eruption (PLE), actinic prurigo (AP) and rosacea were tested for the presence of IgM, IgG and IgA antibodies to C trachomatis by ELISA method. The results were compared with 30 healthy controls.
RESULTS: Seventeen (25.53%) of 57 cases of photosensitivity as against two (6.67%) controls were seropositive for IgM/IgG/IgA antibodies, a statistically significant difference (χ(2) 6.18, p 0.013). Similarly, significantly higher seropositivity was observed in 12 (25.53%) of 47 cases of melasma (χ(2) 4.38, p 0.0363) and six (46.15%) of 13 cases with CAD (χ(2) 6.91, p 0.0086). Although higher proportion of patients of rosacea [five (31.25%) of 16 cases] and PLE [four (25.0%) of 16 cases] were seropositive, the difference was not statistically significant (χ(2) 3.23, p >0.05, OR 6.36, CI 95% 0 to 48 and χ(2) 3.09, p 0.078, OR 4.67, CI 95% 5 to 41 respectively). There was no association of AP.
CONCLUSIONS: The observations suggest that C trachomatis infection in non LGV cases is an important cause of PS, melasma and CAD. It appears to be an important cause of rosacea and PLE. We recommend that all cases of photosensitivity, melasma, CAD, PMLE and rosacea and their spouses/sexual contacts be investigated for C trachomatis infection.
METHODS: Sera of all the cases of photosensitivity, melasma, chronic actinic dermatitis (CAD), polymorphic light eruption (PLE), actinic prurigo (AP) and rosacea were tested for the presence of IgM, IgG and IgA antibodies to C trachomatis by ELISA method. The results were compared with 30 healthy controls.
RESULTS: Seventeen (25.53%) of 57 cases of photosensitivity as against two (6.67%) controls were seropositive for IgM/IgG/IgA antibodies, a statistically significant difference (χ(2) 6.18, p 0.013). Similarly, significantly higher seropositivity was observed in 12 (25.53%) of 47 cases of melasma (χ(2) 4.38, p 0.0363) and six (46.15%) of 13 cases with CAD (χ(2) 6.91, p 0.0086). Although higher proportion of patients of rosacea [five (31.25%) of 16 cases] and PLE [four (25.0%) of 16 cases] were seropositive, the difference was not statistically significant (χ(2) 3.23, p >0.05, OR 6.36, CI 95% 0 to 48 and χ(2) 3.09, p 0.078, OR 4.67, CI 95% 5 to 41 respectively). There was no association of AP.
CONCLUSIONS: The observations suggest that C trachomatis infection in non LGV cases is an important cause of PS, melasma and CAD. It appears to be an important cause of rosacea and PLE. We recommend that all cases of photosensitivity, melasma, CAD, PMLE and rosacea and their spouses/sexual contacts be investigated for C trachomatis infection.
摘要：
背景：在几乎50％的由L1，L2或L3血清型引起的淋巴肉芽肿性病（LGV）慢性病例中，已经描述了对沙眼衣原体的光敏性。尚未研究沙眼衣原体非LGV菌株的光敏性。我们研究了非LGV病例中各种光敏性皮肤病与沙眼衣原体感染的关系。
方法：所有光敏病例的血清，黄褐斑,慢性光化性皮炎（CAD），多态光喷发（PLE），测试了光化性痒疹（AP）和酒渣鼻是否存在IgM，采取ELISA法检测沙眼衣原体IgG和IgA抗体。将结果与30名健康对照进行比较。
结果：57例光敏性病例中有17例（25.53％）与2例（6.67％）对照相比，IgM/IgG/IgA抗体呈血清阳性，差异有统计学意义(χ(2)6.18，p=0.013)。同样，在47例黄褐斑患者中的12例（25.53％）（χ（2）4.38，p0.0363）和13例CAD患者中的6例（46.15％）（χ（2）6.91，p0.0086）中观察到了显着更高的血清阳性。尽管酒渣鼻[16例中有5例（31.25%）]和PLE[16例中有4例（25.0%）]患者血清阳性的比例较高，差异无统计学意义(χ(2)3.23,p>0.05,OR6.36,CI95%0~48,χ(2)3.09,p0.078,OR4.67,CI95%5~41)。没有AP的关联。
结论：观察结果表明，非LGV病例中沙眼衣原体感染是PS的重要原因，黄褐斑和CAD。这似乎是酒渣鼻和PLE的重要原因。我们建议所有光敏性病例,黄褐斑,CAD,对PMLE和酒渣鼻及其配偶/性接触者进行沙眼衣原体感染调查。
方法：所有光敏病例的血清，黄褐斑,慢性光化性皮炎（CAD），多态光喷发（PLE），测试了光化性痒疹（AP）和酒渣鼻是否存在IgM，采取ELISA法检测沙眼衣原体IgG和IgA抗体。将结果与30名健康对照进行比较。
结果：57例光敏性病例中有17例（25.53％）与2例（6.67％）对照相比，IgM/IgG/IgA抗体呈血清阳性，差异有统计学意义(χ(2)6.18，p=0.013)。同样，在47例黄褐斑患者中的12例（25.53％）（χ（2）4.38，p0.0363）和13例CAD患者中的6例（46.15％）（χ（2）6.91，p0.0086）中观察到了显着更高的血清阳性。尽管酒渣鼻[16例中有5例（31.25%）]和PLE[16例中有4例（25.0%）]患者血清阳性的比例较高，差异无统计学意义(χ(2)3.23,p>0.05,OR6.36,CI95%0~48,χ(2)3.09,p0.078,OR4.67,CI95%5~41)。没有AP的关联。
结论：观察结果表明，非LGV病例中沙眼衣原体感染是PS的重要原因，黄褐斑和CAD。这似乎是酒渣鼻和PLE的重要原因。我们建议所有光敏性病例,黄褐斑,CAD,对PMLE和酒渣鼻及其配偶/性接触者进行沙眼衣原体感染调查。
