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Abstract：
BACKGROUND: Discussion of the relevance of suitable experimental models for the effective translation of drug effects to clinical inflammatory diseases has a long history. Much emphasis is placed these days on genetically transformed mice, which may have developmental drawbacks. But are established models redundant?
RESULTS: Drawn from personal experience, examples are provided of the success of tinkering with technology in the context of inflammation. These include the use of specific dietary deficiency conditions, the development of new applications for established drugs and the introduction of a variety of readouts to assess outcome in studies on established disease models. Such approaches have been used to demonstrate inflammation-modulating effects of prostaglandin E, in the development of ebselen, for the introduction of immunomodulatory macrolide drugs and in new approaches to the therapy of multiple sclerosis.
CONCLUSIONS: Fine tuning of experimental approaches and evaluation technologies can often still provide innovative, clinically relevant insights into the potential beneficial effects of drugs and pharmacological agents.
RESULTS: Drawn from personal experience, examples are provided of the success of tinkering with technology in the context of inflammation. These include the use of specific dietary deficiency conditions, the development of new applications for established drugs and the introduction of a variety of readouts to assess outcome in studies on established disease models. Such approaches have been used to demonstrate inflammation-modulating effects of prostaglandin E, in the development of ebselen, for the introduction of immunomodulatory macrolide drugs and in new approaches to the therapy of multiple sclerosis.
CONCLUSIONS: Fine tuning of experimental approaches and evaluation technologies can often still provide innovative, clinically relevant insights into the potential beneficial effects of drugs and pharmacological agents.
摘要：
背景：关于将药物作用有效转化为临床炎性疾病的合适实验模型的讨论已有很长的历史。如今，人们非常重视转基因小鼠，这可能有发展上的缺点。但是建立的模型是多余的吗？
结果：根据个人经验得出，提供了在炎症背景下修补技术成功的例子。这些包括使用特定的饮食缺乏条件，开发已建立药物的新应用，并引入各种读数以评估已建立疾病模型研究的结果。这些方法已被用于证明前列腺素E的炎症调节作用，在ebselen的发展过程中,用于引入免疫调节大环内酯类药物和治疗多发性硬化症的新方法。
结论：实验方法和评估技术的微调通常仍然可以提供创新，对药物和药物的潜在有益作用的临床相关见解。
结果：根据个人经验得出，提供了在炎症背景下修补技术成功的例子。这些包括使用特定的饮食缺乏条件，开发已建立药物的新应用，并引入各种读数以评估已建立疾病模型研究的结果。这些方法已被用于证明前列腺素E的炎症调节作用，在ebselen的发展过程中,用于引入免疫调节大环内酯类药物和治疗多发性硬化症的新方法。
结论：实验方法和评估技术的微调通常仍然可以提供创新，对药物和药物的潜在有益作用的临床相关见解。
