Abstract：
OBJECTIVE: The chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs) can cause complications in the gastrointestinal tract. The use of proton pump inhibitors (PPIs) is recommended in high-risk patients to prevent them.
OBJECTIVE: The aim of this article was to evaluate the gastroprotection measures taken in persons with chronic NSAID use.
METHODS: A descriptive cross-sectional study was conducted. The clinical records were reviewed of patients seen as outpatients at the Rheumatology Department over a 4-month period, choosing those with chronic NSAID use, and intentionally looking for gastroprotection measures according to the recommendations published by the American College of Gastroenterology.
RESULTS: A total of 417 patients (347 women; mean age: 48.12±14.2 years) were included. The most frequent diagnosis was rheumatoid arthritis (65%). Nine patients (2.1%) had a history of peptic ulcer, 48 (11.5%) patients were 65 years of age or older, 26 (6.2%) patients took NSAIDs and aspirin, and 130 (31.2%) took NSAIDs with steroids. Tests for Helicobacter pylori infection were done in just 53 cases, and there were positive results in only 9 (16%). Some risk for gastrointestinal toxicity was established in 211 cases and only 65 (30.8%) received gastroprotection. In contrast, 31 (15%) patients received gastroprotection when there was no indication for it.
CONCLUSIONS: Prophylaxis with PPIs in chronic NSAID users was inadequately employed. It was not prescribed in the majority of patients (69.2%) and it was used with no justification in others (15%).
OBJECTIVE: The aim of this article was to evaluate the gastroprotection measures taken in persons with chronic NSAID use.
METHODS: A descriptive cross-sectional study was conducted. The clinical records were reviewed of patients seen as outpatients at the Rheumatology Department over a 4-month period, choosing those with chronic NSAID use, and intentionally looking for gastroprotection measures according to the recommendations published by the American College of Gastroenterology.
RESULTS: A total of 417 patients (347 women; mean age: 48.12±14.2 years) were included. The most frequent diagnosis was rheumatoid arthritis (65%). Nine patients (2.1%) had a history of peptic ulcer, 48 (11.5%) patients were 65 years of age or older, 26 (6.2%) patients took NSAIDs and aspirin, and 130 (31.2%) took NSAIDs with steroids. Tests for Helicobacter pylori infection were done in just 53 cases, and there were positive results in only 9 (16%). Some risk for gastrointestinal toxicity was established in 211 cases and only 65 (30.8%) received gastroprotection. In contrast, 31 (15%) patients received gastroprotection when there was no indication for it.
CONCLUSIONS: Prophylaxis with PPIs in chronic NSAID users was inadequately employed. It was not prescribed in the majority of patients (69.2%) and it was used with no justification in others (15%).
摘要：
目的：长期使用非甾体抗炎药（NSAIDs）可引起胃肠道并发症。建议在高危患者中使用质子泵抑制剂（PPI）以预防它们。
目的：本文的目的是评估长期使用NSAID的患者的胃保护措施。
方法：进行描述性横断面研究。在四个月的时间内，对风湿科门诊患者的临床记录进行了回顾，选择那些长期使用NSAID的人，并根据美国胃肠病学会发布的建议有意寻找胃保护措施。
结果：共纳入417例患者（347名女性；平均年龄：48.12±14.2岁）。最常见的诊断是类风湿性关节炎（65%）。9例(2.1%)有消化性溃疡病史,48例（11.5％）患者年龄在65岁或以上，26例（6.2%）患者服用非甾体抗炎药和阿司匹林，130例(31.2%)服用非甾体抗炎药和类固醇。仅53例进行了幽门螺杆菌感染检测，只有9例(16%)出现阳性结果。在211例中确定了胃肠道毒性的风险，只有65例（30.8％）接受了胃保护。相比之下,31名（15％）患者在没有适应症的情况下接受了胃保护。
结论：在慢性NSAID使用者中使用PPI预防没有得到充分应用。大多数患者（69.2％）没有处方，其他患者（15％）没有理由使用。
目的：本文的目的是评估长期使用NSAID的患者的胃保护措施。
方法：进行描述性横断面研究。在四个月的时间内，对风湿科门诊患者的临床记录进行了回顾，选择那些长期使用NSAID的人，并根据美国胃肠病学会发布的建议有意寻找胃保护措施。
结果：共纳入417例患者（347名女性；平均年龄：48.12±14.2岁）。最常见的诊断是类风湿性关节炎（65%）。9例(2.1%)有消化性溃疡病史,48例（11.5％）患者年龄在65岁或以上，26例（6.2%）患者服用非甾体抗炎药和阿司匹林，130例(31.2%)服用非甾体抗炎药和类固醇。仅53例进行了幽门螺杆菌感染检测，只有9例(16%)出现阳性结果。在211例中确定了胃肠道毒性的风险，只有65例（30.8％）接受了胃保护。相比之下,31名（15％）患者在没有适应症的情况下接受了胃保护。
结论：在慢性NSAID使用者中使用PPI预防没有得到充分应用。大多数患者（69.2％）没有处方，其他患者（15％）没有理由使用。
