关键词: Beauveria bassiana Contact lenses Fungal keratitits Natamycin Voriconazole

Mesh : Antifungal Agents / administration & dosage Beauveria / classification genetics isolation & purification Contact Lenses / adverse effects Debridement Female Humans Keratitis / etiology pathology therapy Middle Aged Mycoses / diagnosis pathology therapy Treatment Outcome

来  源:   DOI:10.1007/s11046-016-0027-2

Abstract:
Fungal keratitis is a severe ocular infection that primarily affects subjects engaged in outdoor activities. Risk factors include allergic conjunctivitis, previous eye surgery, previous treatment with wide-spectrum antimicrobial agents and corticosteroids and using contact lenses. Corneal infection is usually secondary to trauma involving organic material, which is often the only predisposing factor. Early diagnosis based on clinical examination and microbiological investigation (microscopy, cultures and molecular techniques) is crucial to selecting the appropriate antifungal therapy and prevent progression. We report the case of a patient with keratitis due to Beauveria bassiana, an opportunistic and entomopathogenic filamentous fungus that is used as a biological insecticide and which is a rare cause of corneal infection. We review previous cases reports of B. bassiana keratitis published and its main features to compare with our case, a female occasional agriculture worker who had not suffered any trauma involving organic material. The patient received topical and oral antifungal therapy and debridement surgery, with a satisfactory outcome.
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