LncRNA HULC 通过 miR - 200a - 3p / ZEB1 信号通路增强上皮 - 间质转化促进肝癌的发生和转移.
关键词: ZEB1 epithelial-mesenchymal transition hepatocellular carcinoma lncRNA HULC miR-200a-3p
Mesh : Acetylcysteine / metabolism Aged Animals Apoptosis Carcinogenesis Carcinoma, Hepatocellular / genetics metabolism Cell Proliferation Cell Transformation, Neoplastic / genetics Disease Progression Epithelial-Mesenchymal Transition Female Humans Lentivirus / genetics Liver / metabolism Liver Neoplasms / genetics metabolism Male Mice Mice, Inbred BALB C Mice, Nude MicroRNAs / genetics metabolism Middle Aged Neoplasm Metastasis Neoplasm Transplantation RNA, Long Noncoding / metabolism RNA, Small Interfering / metabolism Signal Transduction Zinc Finger E-box-Binding Homeobox 1 / genetics metabolism
来 源:
DOI:10.18632/oncotarget.9883
PDF(Pubmed)