关键词: Confocal microscopy Fusarium solani Hyperreflective lines Mycotic keratitis Relapse marker

Mesh : Biomarkers Corneal Transplantation / methods Diagnostic Techniques, Ophthalmological Early Diagnosis Female Fusariosis / diagnostic imaging pathology surgery Humans Keratitis / diagnostic imaging pathology surgery Microscopy, Confocal / methods Middle Aged Recurrence Treatment Outcome

来  源:   DOI:10.1007/s00347-016-0270-4   PDF(Sci-hub)

Abstract:
In the case of therapy-resistant keratitis an infection with Fusarium solani should be taken into consideration as a rare but very severe eye disease. In the majority of cases Fusarium solani keratitis will result in a protracted clinical course despite aggressive medicinal and surgical interventions. We describe the case of a referred patient after intensive topical, intracameral and systemic antibacterial and antimycotic therapy as well as surgical treatment with emergency keratoplasty à chaud because of Fusarium solani keratitis. The patient presented to our department with persistent discomfort for further therapeutic interventions. Using confocal microscopy we were able to demonstrate the presence of fungal hyphae in the host cornea and the graft, which was important for making further surgical decisions. Furthermore, this emphasizes the role of confocal microscopy as an early relapse marker during the clinical monitoring.
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