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Abstract：
The hair follicle (HF) has a wide range of functions including thermoregulation, physical and immunological protection against external insults, sensory perception, social interactions, and camouflage. One of the most characteristic features of HFs is that they self-renew during hair cycle (HC) throughout the entire life of an individual to continuously produce new hair. HC disturbances are common in humans and comparable to some alopecic disorders in dogs. A normal HC is maintained by follicular stem cells (SCs), which are predominately found in an area known as the bulge. Due to similar morphological characteristics of the human and canine bulge area, the particularity of compound HFs in humans and dogs as well as similarities in follicular biomarker expression, the dog might be a promising model to study human HC and SC disorders. In this review, we give an overview of normal follicular anatomy, the HC, and follicular SCs and discuss the possible pathogenetic mechanisms of noninflammatory alopecia.
摘要：
毛囊（HF）具有广泛的功能，包括温度调节，身体和免疫保护免受外部伤害，感官知觉，社交互动,和伪装。HFs的最典型特征之一是它们在个体的整个生命中在毛发周期(HC)期间自我更新以连续产生新的毛发。HC紊乱在人类中很常见，可与狗中的某些疾病相媲美。正常的HC由滤泡干细胞（SCs）维持，主要发现在一个被称为凸起的区域。由于人类和犬类凸起区域的形态特征相似，人类和狗中复合HFs的特殊性以及卵泡生物标志物表达的相似性，这种狗可能是研究人类HC和SC疾病的有前途的模型。在这次审查中,我们概述了正常的卵泡解剖结构，HC,并探讨非炎症性脱发的可能发病机制。
