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Abstract：
OBJECTIVE: to evaluate alcohol/tobacco/illicit drug use and sexual function in adolescent juvenile idiopathic arthritis (JIA) and healthy controls.
METHODS: 174 adolescents with pediatric rheumatic diseases were selected. A cross-sectional study with 54 JIA patients and 35 controls included demographic/anthropometric data and puberty markers assessments, physician-conducted CRAFFT (car/relax/alone/forget/friends/trouble) screen tool for substance abuse/dependence high risk and a questionnaire that evaluated sexual function, bullying and alcohol/tobacco/illicit drug use. Clinical/laboratorial data and treatment were also assessed in JIA.
RESULTS: The median current age was similar between JIA patients and controls [15(10-19) vs. 15(12-18)years, p=0.506]. Frequencies of alcohol/tobacco/illicit drug use were high and similar in both JIA and controls (43% vs. 46%, p=0.829). However, age at alcohol onset was significantly higher in those with JIA [15(11-18) vs. 14(7-18)years, p=0.032], particularly in poliarticular onset (p=0.040). High risk for substance abuse/dependence (CRAFFT score≥2) was found in both groups (13% vs. 15%, p=1.000), likewise bullying (p=0.088). Further analysis of JIA patients regarding alcohol/tobacco/illicit drug use showed that the median current age [17(14-19) vs. 13(10-19)years, p<0.001] and education years [11(6-13) vs. 7(3-12)years, p<0.001] were significant higher in those that used substances. Sexual activity was significantly higher in the former group (48% vs. 7%, p<0.001). A positive correlation was evidenced between CRAFFT score and current age in JIA patients (p=0.032, r=+0.296).
CONCLUSIONS: A high risk for substance abuse/dependence was observed in both JIA and controls. JIA substance users were more likely to have sexual intercourse. Therefore, routine screening is suggested in all visits of JIA adolescents.
METHODS: 174 adolescents with pediatric rheumatic diseases were selected. A cross-sectional study with 54 JIA patients and 35 controls included demographic/anthropometric data and puberty markers assessments, physician-conducted CRAFFT (car/relax/alone/forget/friends/trouble) screen tool for substance abuse/dependence high risk and a questionnaire that evaluated sexual function, bullying and alcohol/tobacco/illicit drug use. Clinical/laboratorial data and treatment were also assessed in JIA.
RESULTS: The median current age was similar between JIA patients and controls [15(10-19) vs. 15(12-18)years, p=0.506]. Frequencies of alcohol/tobacco/illicit drug use were high and similar in both JIA and controls (43% vs. 46%, p=0.829). However, age at alcohol onset was significantly higher in those with JIA [15(11-18) vs. 14(7-18)years, p=0.032], particularly in poliarticular onset (p=0.040). High risk for substance abuse/dependence (CRAFFT score≥2) was found in both groups (13% vs. 15%, p=1.000), likewise bullying (p=0.088). Further analysis of JIA patients regarding alcohol/tobacco/illicit drug use showed that the median current age [17(14-19) vs. 13(10-19)years, p<0.001] and education years [11(6-13) vs. 7(3-12)years, p<0.001] were significant higher in those that used substances. Sexual activity was significantly higher in the former group (48% vs. 7%, p<0.001). A positive correlation was evidenced between CRAFFT score and current age in JIA patients (p=0.032, r=+0.296).
CONCLUSIONS: A high risk for substance abuse/dependence was observed in both JIA and controls. JIA substance users were more likely to have sexual intercourse. Therefore, routine screening is suggested in all visits of JIA adolescents.
摘要：
目的：评估青少年特发性关节炎（JIA）和健康对照者的酒精/烟草/非法药物使用和性功能。
方法：选取儿童风湿性疾病青少年174例。一项针对54名JIA患者和35名对照的横断面研究包括人口统计学/人体测量数据和青春期标志物评估，医生进行的CRAFFT（汽车/放松/独自/忘记/朋友/麻烦）屏幕工具，用于药物滥用/依赖高风险和评估性功能的问卷，欺凌和酒精/烟草/非法药物使用。JIA还评估了临床/实验室数据和治疗。
结果：JIA患者和对照组的中位当前年龄相似[15（10-19）与15(12-18)年,p=0.506]。在JIA和对照组中，酒精/烟草/非法药物的使用频率很高，并且相似（43％vs.46%,p=0.829)。然而,JIA患者的饮酒年龄明显较高[15（11-18）与14(7-18)年,p=0.032],特别是在脊髓灰质炎发作（p=0.040）。两组均发现药物滥用/依赖的高风险（CRAFFT评分≥2）（13％vs.15%,p=1.000),同样的欺凌（p=0.088）。对JIA患者关于酒精/烟草/非法药物使用的进一步分析表明，当前年龄中位数[17（14-19）与13（10-19）年，p<0.001]和教育年限[11（6-13）vs.7(3-12)年,p<0.001]在使用物质的那些中显著较高。前一组的性活动明显更高(48%vs.7%,p<0.001)。JIA患者的CRAFFT评分与当前年龄呈正相关（p=0.032，r=0.296）。
结论：在JIA和对照组中都观察到药物滥用/依赖的高风险。JIA物质使用者更有可能发生性交。因此,建议在JIA青少年的所有就诊中进行常规筛查。
方法：选取儿童风湿性疾病青少年174例。一项针对54名JIA患者和35名对照的横断面研究包括人口统计学/人体测量数据和青春期标志物评估，医生进行的CRAFFT（汽车/放松/独自/忘记/朋友/麻烦）屏幕工具，用于药物滥用/依赖高风险和评估性功能的问卷，欺凌和酒精/烟草/非法药物使用。JIA还评估了临床/实验室数据和治疗。
结果：JIA患者和对照组的中位当前年龄相似[15（10-19）与15(12-18)年,p=0.506]。在JIA和对照组中，酒精/烟草/非法药物的使用频率很高，并且相似（43％vs.46%,p=0.829)。然而,JIA患者的饮酒年龄明显较高[15（11-18）与14(7-18)年,p=0.032],特别是在脊髓灰质炎发作（p=0.040）。两组均发现药物滥用/依赖的高风险（CRAFFT评分≥2）（13％vs.15%,p=1.000),同样的欺凌（p=0.088）。对JIA患者关于酒精/烟草/非法药物使用的进一步分析表明，当前年龄中位数[17（14-19）与13（10-19）年，p<0.001]和教育年限[11（6-13）vs.7(3-12)年,p<0.001]在使用物质的那些中显著较高。前一组的性活动明显更高(48%vs.7%,p<0.001)。JIA患者的CRAFFT评分与当前年龄呈正相关（p=0.032，r=0.296）。
结论：在JIA和对照组中都观察到药物滥用/依赖的高风险。JIA物质使用者更有可能发生性交。因此,建议在JIA青少年的所有就诊中进行常规筛查。
