Abstract：
The finding of hardening and thickening of the skin is common and can be encountered in immune mediated, metabolic, neoplastic, toxic, genetic diseases, or associated with protein deposits. The lack of Raynaud\'s phenomenon, capillaroscopic abnormalities, or scleroderma-specific autoantibodies should question the diagnosis of scleroderma and trigger the search for a scleroderma-like disorder, for which treatment and prognosis differ. This article gives a review of these disorders and their main characteristics.
摘要：
皮肤硬化和增厚的发现是常见的，可以在免疫介导的情况下遇到，新陈代谢，肿瘤，有毒,遗传性疾病,或与蛋白质沉积物有关。缺乏雷诺现象，毛细血管镜异常,或硬皮病特异性自身抗体应该质疑硬皮病的诊断，并引发对硬皮病样疾病的搜索，治疗和预后不同。本文对这些疾病及其主要特征进行了综述。
