关键词: Antiausterity agent Caesalpinia sappan Caesalpiniaceae Cassane diterpene PANC-1

Mesh : Caesalpinia / chemistry Cell Line, Tumor Diterpenes / chemistry isolation & purification pharmacology Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pancreatic Neoplasms / drug therapy Seeds / chemistry

来  源:   DOI:10.1016/j.phytochem.2015.12.018

Abstract:
Eight structurally diverse cassane diterpenes named tomocins A-H were isolated from the seed kernels of Vietnamese Caesalpinia sappan Linn. Their structures were determined by extensive NMR and CD spectroscopic analysis. Among the isolated compounds, tomocin A, phanginin A, F, and H exhibited mild preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived condition without causing toxicity in normal nutrient-rich conditions.
摘要:
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