%0 Journal Article
%T Cassane diterpenes from the seed kernels of Caesalpinia sappan.
%A Nguyen HX
%A Nguyen NT
%A Dang PH
%A Thi Ho P
%A Nguyen MTT
%A Van Can M
%A Dibwe DF
%A Ueda JY
%A Awale S
%J Phytochemistry
%V 122
%N 0
%D Feb 2016
%M 26769396
%F 4.004
%R 10.1016/j.phytochem.2015.12.018
%X Eight structurally diverse cassane diterpenes named tomocins A-H were isolated from the seed kernels of Vietnamese Caesalpinia sappan Linn. Their structures were determined by extensive NMR and CD spectroscopic analysis. Among the isolated compounds, tomocin A, phanginin A, F, and H exhibited mild preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived condition without causing toxicity in normal nutrient-rich conditions.