铂 ( Ⅱ ) 配合物 ( 1R ,2R) - N (1) - 环戊基 - 1, 2 - 环己烷二胺, 具有取代的丙二酸酯衍生物。
关键词: Anticancer Cyclopentyl Cytotoxicity Malonate derivatives Platinum(II) complexes
Mesh : Antineoplastic Agents / chemical synthesis chemistry pharmacology Apoptosis / drug effects Cell Line, Tumor Cell Proliferation / drug effects Coordination Complexes / chemical synthesis chemistry pharmacology Cyclohexylamines / chemical synthesis chemistry pharmacology DNA Cleavage / drug effects DNA, Superhelical / drug effects Drug Screening Assays, Antitumor Humans Ligands Malonates / chemical synthesis chemistry pharmacology Organoplatinum Compounds / chemical synthesis pharmacology Platinum / chemistry Structure-Activity Relationship
来 源:
DOI:10.1016/j.bmcl.2015.12.019
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