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Abstract：
BACKGROUND: Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk.
OBJECTIVE: We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort.
METHODS: We assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs.
RESULTS: None of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall HR: 1.21; 95% CI: 1.04, 1.41).
CONCLUSIONS: In the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat.
OBJECTIVE: We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort.
METHODS: We assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs.
RESULTS: None of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall HR: 1.21; 95% CI: 1.04, 1.41).
CONCLUSIONS: In the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat.
摘要：
背景：关于饮食因素在上皮性卵巢癌（EOC）发展中的作用的研究有限，并且没有特定的饮食因素与EOC风险持续相关.
目的：我们采用全营养素关联研究方法，系统地检验了饮食因素与侵袭性EOC风险之间的关联，同时采用错误发现率进行多重假设检验，并在独立队列中评估了结果。
方法：我们在EPIC（欧洲癌症和营养前瞻性调查）研究（n=1095例）中使用膳食问卷评估了28种食物/食物组和29种营养素的膳食摄入量。我们选择了4种与EOC风险显著相关的食物/营养素，比较了EPIC研究中的极端四分位数摄入量（错误发现率=0.43），并在NLCS中评估了这些因素（荷兰队列研究；n=383例）。Cox回归模型用于估计HR和95%CIs。
结果：EPIC研究中与EOC风险相关的4种饮食因素（胆固醇，多不饱和和饱和脂肪，和香蕉)在NLCS中与EOC风险显著相关；然而，在EPIC研究和NLCS的荟萃分析中，我们观察到,饱和脂肪摄入量高的EOC风险高于低的EOC(四分位数4比四分位数1;总体HR:1.21;95%CI:1.04,1.41).
结论：在两项研究的荟萃分析中，与低饱和脂肪摄入量相比,高的EOC风险更高.
目的：我们采用全营养素关联研究方法，系统地检验了饮食因素与侵袭性EOC风险之间的关联，同时采用错误发现率进行多重假设检验，并在独立队列中评估了结果。
方法：我们在EPIC（欧洲癌症和营养前瞻性调查）研究（n=1095例）中使用膳食问卷评估了28种食物/食物组和29种营养素的膳食摄入量。我们选择了4种与EOC风险显著相关的食物/营养素，比较了EPIC研究中的极端四分位数摄入量（错误发现率=0.43），并在NLCS中评估了这些因素（荷兰队列研究；n=383例）。Cox回归模型用于估计HR和95%CIs。
结果：EPIC研究中与EOC风险相关的4种饮食因素（胆固醇，多不饱和和饱和脂肪，和香蕉)在NLCS中与EOC风险显著相关；然而，在EPIC研究和NLCS的荟萃分析中，我们观察到,饱和脂肪摄入量高的EOC风险高于低的EOC(四分位数4比四分位数1;总体HR:1.21;95%CI:1.04,1.41).
结论：在两项研究的荟萃分析中，与低饱和脂肪摄入量相比,高的EOC风险更高.
