通过位点特异性 O - 糖基化调节 ADAM 介导的胞外域脱落的系统研究。
关键词: ACE ADAM10 ErbB4 IL-6RA TACE
Mesh : ADAM Proteins / chemistry metabolism Amino Acid Sequence Animals Blotting, Western Genes, Reporter Glycopeptides / chemistry metabolism Glycosylation / drug effects HEK293 Cells Hep G2 Cells Humans Lipopolysaccharides / pharmacology Mice, Knockout Molecular Sequence Data Mutation / genetics N-Acetylgalactosaminyltransferases / metabolism Protein Structure, Tertiary Substrate Specificity / drug effects Tumor Necrosis Factor-alpha / blood metabolism Polypeptide N-acetylgalactosaminyltransferase
来 源:
DOI:10.1073/pnas.1511175112
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