关键词： behavioral neurodevelopmental pediatric intensive care sepsis-associated encephalopathy

Mesh ： Age Factors Analysis of Variance Case-Control Studies Child Child Behavior Disorders / etiology Child, Preschool Cognition Disorders / etiology Developmental Disabilities / etiology Female Humans Intellectual Disability / diagnosis etiology Intelligence Tests Intensive Care Units, Pediatric Male Neuropsychological Tests Prospective Studies Sepsis-Associated Encephalopathy / complications Severity of Illness Index Verbal Behavior

来  源：   DOI：10.1177/0883073815610431   PDF(Sci-hub)

Abstract：
The authors prospectively compared the neurodevelopmental and behavioral outcomes in 50 consecutive children with sepsis-associated encephalopathy admitted to intensive care unit with healthy controls. Children with sepsis-associated encephalopathy had significantly worse mean verbal IQ, full-scale IQ, General Development Score, and its physical, adaptive, social-emotional, cognitive, and communication subscales. Significant proportion of cases (52% vs 32% in controls) had low intelligence. Decline in school performance (44%), disobedience (28%), and stubbornness/irritable behavior (26%) were the most common behavior changes. Children with Glasgow Coma Scale score ≤10 and ≤8 had impairments in full-scale IQ even though overall Glasgow Coma Scale score did not show significant correlation with developmental outcomes. In conclusion, children with sepsis-associated encephalopathy have delayed neurodevelopment, low verbal IQ, decline in school performance and low intelligence at short-term follow-up. Irritability, shock and duration of sedation are associated with poor behavioral outcomes, especially scholastic performance.
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