Remission of refractory pyoderma gangrenosum, severe acne, and hidradenitis suppurativa (PASH) syndrome using targeted antibiotic therapy in 4 patients.

• 影响指数: 15.487
• 发表时间: Nov 2015
• 来源期刊: J Am Acad Dermatol
• DOI: 10.1016/j.jaad.2015.07.040
• PMID: 26470620
• 文章类型: Journal Article
• 中科院分区: Q1
• 方向: 医学
• 作者列表: Join-Lambert O,Duchatelet S,Delage M,Miskinyte S,Coignard H,Lemarchand N,Alemy-Carreau M,Lortholary O,Nassif X,Hovnanian A,Nassif A

关键词: PASH syndrome; acne fulminans; antibiotic therapy; hidradenitis suppurativa; microbiome host disease; pyoderma gangrenosum; remission; severe acne

Mesh: Acne Vulgaris / complications diagnosis drug therapy surgery; Adult; Anti-Bacterial Agents / therapeutic use; Combined Modality Therapy; Drug Delivery Systems / methods; Female; Follow-Up Studies; Hidradenitis Suppurativa / complications diagnosis drug therapy surgery; Humans; Male; Microbiota / drug effects; Pyoderma Gangrenosum / complications diagnosis drug therapy surgery; Sampling Studies; Severity of Illness Index; Skin / drug effects microbiology; Syndrome; Treatment Outcome; Young Adult

Abstract

Pyoderma gangrenosum, severe acne, and suppurative hidradenitis (PASH) syndrome can prove refractory to treatment and is characterized by relapses and recurrences. The combination of antibiotic therapy and surgery can produce success in the management of the syndrome. Acute treatment is required, but maintenance therapy is also necessary to prevent disease relapse. The response to antibiotic therapy is hypothesis generating, raising the issue of a modified host response. To date, anecdotal reports support the use of surgery and medical therapy, but controlled investigations with extended follow-up are necessary to substantiate preliminary data observed with individual cases.