Abstract：
OBJECTIVE: The present study aimed to gather information on the impact of Alpha/European Society of Human Reproduction and Embryology (ESHRE) consensus regarding oocytes with aggregates of smooth endoplasmic reticulum (SERa) on in vitro fertilization outcome. In particular, we investigated if patients undergoing intracytoplasmic sperm injection (ICSI) and whose oocytes are discarded due to SERa have a higher chance of embryo transfer cancellation compared to patients without SERa oocytes.
METHODS: This is a nested case-control study drawn from the cohort of women referring for in vitro fertilization with ICSI. Cases were patients showing at least one oocyte with SERa at the time of injection. Controls were subsequent patients showing no SERa oocytes and matched ratio 1:1 for age, clinical indication to in vitro fertilization (IVF), and body mass index. The main outcome was the rate of embryo transfer cancellation.
RESULTS: The percentage of women experiencing a transfer cancellation (absence of suitable oocytes or viable embryos) in their ICSI cycle were significantly higher in cases (18 %) compared to controls (8 %) (p = 0.02); however, adjusted odds ratio for FSH and number of SERa oocytes, of follicles, of retrieved oocytes, and of inseminated oocytes were not statistically significant.
CONCLUSIONS: We have shown that the exclusion of SERa oocytes from ICSI cycles causes an increased frequency of transfer cancellation. This effect is mostly due to the reduced number of available oocytes after exclusion of SERa oocytes.
METHODS: This is a nested case-control study drawn from the cohort of women referring for in vitro fertilization with ICSI. Cases were patients showing at least one oocyte with SERa at the time of injection. Controls were subsequent patients showing no SERa oocytes and matched ratio 1:1 for age, clinical indication to in vitro fertilization (IVF), and body mass index. The main outcome was the rate of embryo transfer cancellation.
RESULTS: The percentage of women experiencing a transfer cancellation (absence of suitable oocytes or viable embryos) in their ICSI cycle were significantly higher in cases (18 %) compared to controls (8 %) (p = 0.02); however, adjusted odds ratio for FSH and number of SERa oocytes, of follicles, of retrieved oocytes, and of inseminated oocytes were not statistically significant.
CONCLUSIONS: We have shown that the exclusion of SERa oocytes from ICSI cycles causes an increased frequency of transfer cancellation. This effect is mostly due to the reduced number of available oocytes after exclusion of SERa oocytes.
摘要：
目的：本研究旨在收集有关Alpha/欧洲人类生殖与胚胎学学会（ESHRE）关于卵母细胞与光滑内质网（SERA）聚集体的共识对体外受精结局的影响的信息。特别是,我们调查了接受卵胞浆内单精子注射(ICSI)且由于SERa而丢弃卵母细胞的患者与没有SERa卵母细胞的患者相比,胚胎移植取消的可能性是否更高.
方法：这是一项巢式病例对照研究，来自ICSI体外受精的女性队列。病例为在注射时显示至少一个具有SERa的卵母细胞的患者。对照组是随后的患者，显示没有SERa卵母细胞，年龄匹配比例为1：1，体外受精（IVF）的临床指征，和体重指数。主要结果是胚胎移植取消率。
结果：在ICSI周期中发生转移取消（缺少合适的卵母细胞或有活力的胚胎）的女性比例（18%）明显高于对照组（8%）（p=0.02）；FSH和SERA卵母细胞数量的调整比值比，卵泡，回收的卵母细胞，和授精的卵母细胞没有统计学意义。
结论：我们已经表明，从ICSI周期中排除SERa卵母细胞会导致转移取消的频率增加。这种作用主要是由于在排除SERa卵母细胞后可用的卵母细胞数量减少。
方法：这是一项巢式病例对照研究，来自ICSI体外受精的女性队列。病例为在注射时显示至少一个具有SERa的卵母细胞的患者。对照组是随后的患者，显示没有SERa卵母细胞，年龄匹配比例为1：1，体外受精（IVF）的临床指征，和体重指数。主要结果是胚胎移植取消率。
结果：在ICSI周期中发生转移取消（缺少合适的卵母细胞或有活力的胚胎）的女性比例（18%）明显高于对照组（8%）（p=0.02）；FSH和SERA卵母细胞数量的调整比值比，卵泡，回收的卵母细胞，和授精的卵母细胞没有统计学意义。
结论：我们已经表明，从ICSI周期中排除SERa卵母细胞会导致转移取消的频率增加。这种作用主要是由于在排除SERa卵母细胞后可用的卵母细胞数量减少。
