关键词: B7 family CD28 family HHLA2 TMIGD2 angiogenesis immunosuppression immunotherapy ligand receptor tumor microenvironment

来  源:   DOI:10.1080/2162402X.2015.1026534   PDF(Sci-hub)

Abstract:
We and others recently discovered HHLA2 as a new B7 family member and transmembrane and immunoglobulin domain containing 2 (TMIGD2) as one of its receptors. Based on a new study we propose that HHLA2 may represent a novel immunosuppressive mechanism within the tumor microenvironment and hence could be a target for cancer therapy. TMIGD2 may be another therapeutic target.
摘要:
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