%0 Journal Article
%T HHLA2 and TMIGD2: new immunotherapeutic targets of the B7 and CD28 families.
%A Janakiram M
%A Chinai JM
%A Zhao A
%A Sparano JA
%A Zang X
%J Oncoimmunology
%V 4
%N 8
%D Aug 2015
%M 26405587
暂无%R 10.1080/2162402X.2015.1026534
%X We and others recently discovered HHLA2 as a new B7 family member and transmembrane and immunoglobulin domain containing 2 (TMIGD2) as one of its receptors. Based on a new study we propose that HHLA2 may represent a novel immunosuppressive mechanism within the tumor microenvironment and hence could be a target for cancer therapy. TMIGD2 may be another therapeutic target.