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Abstract：
Claustrum, a gray matter structure that underlies the neocortex, is reciprocally connected with many neocortical and limbic cortical areas. This connectivity positions claustrum ideally for the integration or coordination of widespread cortical activity. In anatomical studies using multiple planes of section, claustrum has distinct subregions based on latexin immunohistochemistry, and an approximately rostro-caudal alignment of fusiform cells supporting a laminar intrinsic organization. Physiological studies of claustral connectivity in disinhibited brain slices demonstrate (1) intrinsic connectivity sufficient to generate spontaneous synchronized burst discharges, (2) activity spread within the oblique laminae that contained the principal cellular axis, and (3) segregation of activity as evidenced by the absence of spread within coronal planes. Activity spread depended on glutamatergic synaptic transmission, and activity restrictions did not depend on inhibitory circuits. We conclude that the claustrum has an intrinsic excitatory connectivity that is constrained in approximately rostro-caudal laminae, with minimal cross-communication between laminae. Further, claustrum has the intrinsic capability of generating synchronized population activity and facilitating its spread within laminae, a feature that may contribute to seizure generation and spread.
摘要：
Claustrum,位于大脑皮层之下的灰质结构，与许多新皮质和边缘皮质区域相互联系。这种连通性理想地将claustrum定位为整合或协调广泛的皮层活动。在使用多个截面平面的解剖学研究中，根据latexin免疫组织化学，claustrum有不同的亚区，和梭形细胞的大致rostro-cudal排列，支持层状内在组织。解除抑制的脑片中的锁骨连通性的生理研究表明（1）足以产生自发同步爆发放电的内在连通性，（2）活动在包含主要细胞轴的斜叶内传播，和（3）活动的隔离，如在冠状平面内没有扩散所证明的。活动传播依赖于谷氨酸能突触传递，和活性限制不依赖于抑制回路。我们得出的结论是，caustrum具有内在的兴奋性连通性，该连通性在大约rostro-caudal椎板中受到限制。薄层之间的交叉交流最小。Further,claustrum具有产生同步种群活动并促进其在叶片内传播的内在能力，一个可能有助于癫痫发作产生和传播的特征。
