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Abstract：
OBJECTIVE: Evidence and consensus-based guidelines for nutrition management of maple syrup urine disease (MSUD) were developed as part of a project to create nutrition guidelines for inherited metabolic disorders identified through newborn screening. The objective of this study was to describe and evaluate the role of evidence analysts in the systematic review phase of guideline development to improve quality of process and output and inform future guideline development projects.
METHODS: Recruitment, training and output of evidence analysts were documented throughout the MSUD project. The role of analysts was to critically review and rate the scientific quality of published literature and abstract pertinent information using quality checklists and abstraction worksheets. A secure, web-based application was developed to standardize the process and establish permanent documentation. Analysts completed a post-project survey on perceptions of their role, training and the evidence analysis process.
RESULTS: Of 23 recruits, 65% (15) completed evidence analyst training; 73% of those (11) participated in the analysis of 98 literature articles. Analysts reviewed a median of four articles (range 1-16) with median productivity of 1.1 articles per month. All analysts surveyed (n = 9) understood their role and agreed that training was adequate; 100% agreed that analyst involvement was critical in developing guidelines for MSUD.
CONCLUSIONS: Evidence analysts played a key role in appraising and abstracting evidence to develop nutrition guidelines for MSUD. With critical improvements to the process, particularly more stringent and systematic evaluation and documentation of analyst performance related to productivity and quality, we will continue to recruit, train and support evidence analysts in evidence-based guideline development projects.
METHODS: Recruitment, training and output of evidence analysts were documented throughout the MSUD project. The role of analysts was to critically review and rate the scientific quality of published literature and abstract pertinent information using quality checklists and abstraction worksheets. A secure, web-based application was developed to standardize the process and establish permanent documentation. Analysts completed a post-project survey on perceptions of their role, training and the evidence analysis process.
RESULTS: Of 23 recruits, 65% (15) completed evidence analyst training; 73% of those (11) participated in the analysis of 98 literature articles. Analysts reviewed a median of four articles (range 1-16) with median productivity of 1.1 articles per month. All analysts surveyed (n = 9) understood their role and agreed that training was adequate; 100% agreed that analyst involvement was critical in developing guidelines for MSUD.
CONCLUSIONS: Evidence analysts played a key role in appraising and abstracting evidence to develop nutrition guidelines for MSUD. With critical improvements to the process, particularly more stringent and systematic evaluation and documentation of analyst performance related to productivity and quality, we will continue to recruit, train and support evidence analysts in evidence-based guideline development projects.
摘要：
目的：枫糖浆尿病（MSUD）营养管理的证据和基于共识的指南是为通过新生儿筛查确定的遗传代谢紊乱制定营养指南项目的一部分。这项研究的目的是描述和评估证据分析师在指南开发的系统审查阶段的作用，以提高过程和输出的质量，并为未来的指南开发项目提供信息。
方法：招聘，在整个MSUD项目中记录了证据分析师的培训和输出。分析师的作用是使用质量清单和抽象工作表批判性地审查和评价已发表文献和抽象相关信息的科学质量。一个安全的，开发了基于Web的应用程序，以使流程标准化并建立永久文档。分析师完成了对其角色的看法的项目后调查，培训和证据分析过程。
结果：在23名新兵中，65%（15）完成了证据分析师培训；其中73%（11）参加了98篇文献文章的分析。分析师审查了四篇文章的中位数（范围1-16），生产率中位数为每月1.1篇。所有接受调查的分析师（n=9）都了解他们的角色，并同意培训是足够的；100％同意分析师的参与对于制定MSUD指南至关重要。
结论：证据分析人员在评估和提取证据以制定MSUD营养指南方面发挥了关键作用。通过对流程的关键改进，特别是对与生产率和质量相关的分析师绩效进行更严格和系统的评估和记录，我们将继续招募，在基于证据的指南开发项目中培训和支持证据分析师。
方法：招聘，在整个MSUD项目中记录了证据分析师的培训和输出。分析师的作用是使用质量清单和抽象工作表批判性地审查和评价已发表文献和抽象相关信息的科学质量。一个安全的，开发了基于Web的应用程序，以使流程标准化并建立永久文档。分析师完成了对其角色的看法的项目后调查，培训和证据分析过程。
结果：在23名新兵中，65%（15）完成了证据分析师培训；其中73%（11）参加了98篇文献文章的分析。分析师审查了四篇文章的中位数（范围1-16），生产率中位数为每月1.1篇。所有接受调查的分析师（n=9）都了解他们的角色，并同意培训是足够的；100％同意分析师的参与对于制定MSUD指南至关重要。
结论：证据分析人员在评估和提取证据以制定MSUD营养指南方面发挥了关键作用。通过对流程的关键改进，特别是对与生产率和质量相关的分析师绩效进行更严格和系统的评估和记录，我们将继续招募，在基于证据的指南开发项目中培训和支持证据分析师。
