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Abstract：
DNA is the prime target of anticancer treatments. DNA damage triggers a series of signaling cascades promoting cellular survival, including DNA repair, cell cycle arrest, and autophagy. The elevated basal and/or stressful levels of both DNA repair and autophagy observed in tumor cells, in contrast to normal cells, have been identified as the most important drug-responsive programs that impact the outcome of anticancer therapy. The exact relationship between DNA repair and autophagy in cancer cells remains unclear. On one hand, autophagy has been shown to regulate some of the DNA repair proteins after DNA damage by maintaining the balance between their synthesis, stabilization, and degradation. One the other hand, some evidence has demonstrated that some DNA repair molecular have a crucial role in the initiation of autophagy. In this review, we mainly discuss the interplay between DNA repair and autophagy in anticancer therapy and expect to enlighten some effective strategies for cancer treatment.
摘要：
DNA是抗癌治疗的主要靶标。DNA损伤引发一系列信号级联，促进细胞存活，包括DNA修复,细胞周期停滞,和自噬。在肿瘤细胞中观察到的DNA修复和自噬的基础和/或应激水平升高，与正常细胞相反,已被确定为影响抗癌治疗结果的最重要的药物反应程序。癌细胞中DNA修复与自噬之间的确切关系尚不清楚。一方面,自噬已被证明在DNA损伤后通过维持其合成之间的平衡来调节一些DNA修复蛋白，稳定,和退化。一只手，有证据表明,一些DNA修复分子在自噬的启动过程中起着至关重要的作用。在这次审查中,我们主要讨论DNA修复和自噬在抗癌治疗中的相互作用，并期望为癌症治疗提供一些有效的策略。
