肿瘤治疗中 DNA 修复与自噬的相互作用.
关键词: AMPK, adenosine monophosphate-activated protein kinase ATG5, autophagy-related gene 5 ATM, ataxia-telangiectasia mutated ATR, ATM and Rad3-related BER, base excision repair Chk1, check-point kinase 1 Chk2, check-point kinase 2 DDR, DNA damage response DNA damage DNA damage response DNA repair DNA-PKcs, DNA-dependent protein kinase catalytic subunit DSBs, double-strand breaks HDAC, histone deacetylases HR, homologous recombination IR, ionizing radiation MGMT, O6 methylguanine –DNA methyltransferase MMR, mismatch repair MRN, Mre11-Rad50-Nbs1 NER, nucleotide excision recombination NHEJ, non-homologous end joining OGG1, 8-oxoguannine DNA glycosidase PARP-1, poly (ADP-ribose) polymerase 1 PI3K, phosphoinositide 3-kinase PML, promyelocytic leukemia SSBs, single-strand break TMZ, temozolomide TSC2, tuberous sclerosis complex 2 anticancer therapy apoptosis autophagy cell cycle arrest mTOR, mammalian target of rapamycin γ-H2AX, phosphorylated histone
Mesh : Apoptosis / genetics Autophagy / genetics Cell Survival / genetics DNA Damage DNA Repair Humans Models, Genetic Neoplasms / genetics metabolism therapy Signal Transduction
来 源:
DOI:10.1080/15384047.2015.1046022
PDF(Sci-hub)