METHODS: 243 MetS individuals participated in a nested case-control design, of whom 63 were excluded (study subjects for analysis n=180; 87 MetS cases, 93 controls). We employed the International Diabetes Federation criteria using national waist circumference cutoffs for case definition. Anthropometric and biochemical measurements were done using standard methods.
RESULTS: Plasma MMP-8, TIMP-1, tumor necrosis factor-alpha (TNF-α), highly sensitive C-reactive protein (hs-CRP) and MMP-8/TIMP-1 ratio were significantly higher in MetS cases (P for all < 0.05). Each component of MetS except raised fasting plasma glucose positively correlated with MMP-8 and numbers of MetS components increased with higher MMP-8. In all regression models, MMP-8 was a significant predictor of MetS and in the final model the relationship persisted even after adjusting for pro-inflammatory cytokines hs-CRP and TNF-α (odds ratio=6.008, 95% confidence interval: 1.612-22.389, P=0.008).
CONCLUSIONS: Strong associations of MMP-8 with components of MetS in univariate, bivariate and multivariate models suggest plasma MMP-8 as a potential cardiometabolic risk marker for MetS. Higher MMP-8 in MetS is possibly mediated through mechanisms both dependent and independent of chronic low grade inflammation.
方法:243名MetS个人参与了嵌套病例对照设计,其中63例被排除在外(用于分析的研究对象n=180;87例MetS病例,93个控件)。我们采用国际糖尿病联合会标准,使用国家腰围截止值作为病例定义。使用标准方法进行人体测量和生化测量。
结果:血浆MMP-8,TIMP-1,肿瘤坏死因子-α(TNF-α),高敏C反应蛋白(hs-CRP)和MMP-8/TIMP-1比值明显高于MetS患者(P均<0.05)。除空腹血糖升高外,MetS的每个成分均与MMP-8呈正相关,并且随着MMP-8的升高,MetS成分的数量增加。在所有回归模型中,MMP-8是MetS的重要预测因子,在最终模型中,即使在调整促炎细胞因子hs-CRP和TNF-α后,这种关系仍然存在(比值比=6.008,95%置信区间:1.612-22.389,P=0.008)。
结论:单变量中MMP-8与MetS成分的强关联,双变量和多变量模型提示血浆MMP-8是MetS的潜在心脏代谢风险标志物.MetS中更高的MMP-8可能是通过依赖和独立于慢性低度炎症的机制介导的。