α - SMA - Cre 介导的 PDK1 切除揭示了 PDK1 在调节心肌细胞形态和组织微环境中肿瘤进展中的重要作用。
关键词: Dilatation cardiaque Heart failure Knock-out mice Microenvironment Microenvironnement PDK1 Souris knock-out Tumeur Tumor
Mesh : Actins / genetics Animals Cardiomyopathy, Dilated / genetics pathology Cell Shape / genetics Disease Progression Female Gene Deletion Gene Knockout Techniques Integrases / genetics Male Mice Mice, Inbred C57BL Mice, Knockout Myocytes, Cardiac / metabolism pathology physiology Neoplasm Metastasis Neoplasms / genetics pathology Protein Serine-Threonine Kinases / genetics Pyruvate Dehydrogenase Acetyl-Transferring Kinase Tumor Cells, Cultured Tumor Microenvironment / genetics
来 源: DOI:10.1016/j.patbio.2014.12.004