A review of the expected effects of antimicrobials in bovine respiratory disease treatment and control using outcomes from published randomized clinical trials with negative controls.

• 影响指数: 4.69
• 发表时间: Mar 2015
• 来源期刊: Vet Clin North Am Food Anim Pract
• DOI: 10.1016/j.cvfa.2014.11.003
• PMID: 25578389
• 文章类型: Journal Article
• 作者列表: DeDonder KD,Apley MD

关键词: Antibiotic resistance; Antibiotic susceptibility; Antimicrobial drugs; Bovine respiratory disease; Evidence based medicine; Number needed to treat; Randomized clinical trial

Mesh: Animals; Anti-Bacterial Agents / therapeutic use; Anti-Infective Agents / therapeutic use; Bovine Respiratory Disease Complex / drug therapy; Cattle; Female; Randomized Controlled Trials as Topic / veterinary; Treatment Outcome

Abstract

Bovine respiratory disease (BRD) remains a major disease from an economic and an animal welfare standpoint in beef production systems. Antimicrobial administration is a mainstay in the control of and therapeutic treatment of acute BRD. Judicious use of antimicrobials remains paramount to ensure efficacy of treatment remains acceptable. A systemic review was conducted in the scientific literature, the objective of which was to present a cumulative review of the data from published randomized clinical trials using a negative control in the treatment and control of BRD and using the number needed to treat as a means to effectively convey this information to bovine practitioners.