{Reference Type}: Journal Article {Title}: A review of the expected effects of antimicrobials in bovine respiratory disease treatment and control using outcomes from published randomized clinical trials with negative controls. {Author}: DeDonder KD;Apley MD; {Journal}: Vet Clin North Am Food Anim Pract {Volume}: 31 {Issue}: 1 {Year}: Mar 2015 {Factor}: 4.69 {DOI}: 10.1016/j.cvfa.2014.11.003 {Abstract}: Bovine respiratory disease (BRD) remains a major disease from an economic and an animal welfare standpoint in beef production systems. Antimicrobial administration is a mainstay in the control of and therapeutic treatment of acute BRD. Judicious use of antimicrobials remains paramount to ensure efficacy of treatment remains acceptable. A systemic review was conducted in the scientific literature, the objective of which was to present a cumulative review of the data from published randomized clinical trials using a negative control in the treatment and control of BRD and using the number needed to treat as a means to effectively convey this information to bovine practitioners.