Mesh : Administration, Oral Aging / drug effects metabolism pathology Animals Cerium / administration & dosage chemistry pharmacology Dose-Response Relationship, Drug Gonadal Hormones / metabolism Leydig Cells / drug effects metabolism pathology Male Nanoparticles Prostate / drug effects metabolism pathology Rats Rats, Wistar Reproduction / drug effects Testis / drug effects metabolism pathology

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Abstract:
The influence of nanocrystalline cerium dioxide (NCD, 1 and 100 mg/kg per os daily for 10 days) on morphofuctional state of reproductive system was investigated in ageing male rats. It has been established that activation of hormone-producing testicular Leydig\'s cells, as well as of secretory and proliferative processes in prostate, underlies the stimulating effect of NCD at a dose 1 mg/kg on hormonal function of testis and spermatogenesis of ageing male rats. NCD used at a dose 100 mg/kg had no significant effect on the assessed indices of morphofuctional state of reproductive system.
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