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Abstract：
BACKGROUND: Stroke after open heart surgery is a major cause of morbidity and mortality. Up to 60% of intraoperative cerebral events are caused by emboli generated by manipulations of the aorta during surgery. This is the first animal study evaluating the safety and efficacy of a novel aortic cannula designed to extract solid and gaseous emboli during cardiac surgery.
METHODS: Seven domestic pigs were connected to cardiopulmonary bypass using a CardioGard 24F aortic cannula. Three pigs that were cannulated with a standard aortic cannula were defined as controls. Several main flow and suction regimens were carried out. Osseous particles of different sizes were injected into the proximal aorta to simulate emboli.
RESULTS: The CardioGard cannula demonstrated an overall emboli retrieval rate of 77%. A rate of 88.45% was demonstrated during the low-flow regimen used clinically during aortic manipulation. Gaseous and solid emboli were eliminated by suction, as demonstrated by epi-carotid ultrasound. No significant changes were observed in hemodynamic and laboratory parameters.
CONCLUSIONS: The CardioGard cannula is as simple to use as a regular commercially available aortic cannula, having a similar safety profile and proven efficacy in capturing intraoperative emboli.
METHODS: Seven domestic pigs were connected to cardiopulmonary bypass using a CardioGard 24F aortic cannula. Three pigs that were cannulated with a standard aortic cannula were defined as controls. Several main flow and suction regimens were carried out. Osseous particles of different sizes were injected into the proximal aorta to simulate emboli.
RESULTS: The CardioGard cannula demonstrated an overall emboli retrieval rate of 77%. A rate of 88.45% was demonstrated during the low-flow regimen used clinically during aortic manipulation. Gaseous and solid emboli were eliminated by suction, as demonstrated by epi-carotid ultrasound. No significant changes were observed in hemodynamic and laboratory parameters.
CONCLUSIONS: The CardioGard cannula is as simple to use as a regular commercially available aortic cannula, having a similar safety profile and proven efficacy in capturing intraoperative emboli.
摘要：
背景：心脏直视手术后的卒中是发病率和死亡率的主要原因。多达60％的术中脑事件是由手术期间主动脉操作产生的栓塞引起的。这是第一项动物研究，旨在评估在心脏手术中提取固体和气体栓塞的新型主动脉插管的安全性和有效性。
方法:使用CardioGard24F主动脉插管将7只家猪连接到体外循环。用标准主动脉套管插管的三只猪被定义为对照。进行了几种主要的流动和抽吸方案。将不同大小的骨颗粒注入近端主动脉以模拟栓塞。
结果：CardioGard套管显示总栓子取回率为77%。在主动脉操作期间临床使用的低流量方案中，证实了88.45％的比率。气体和固体栓塞通过抽吸消除，正如颈动脉超声所证明的。血液动力学和实验室参数未观察到显着变化。
结论：CardioGard插管与常规的市售主动脉插管一样易于使用，在捕获术中栓塞方面具有相似的安全性和已证实的功效。
方法:使用CardioGard24F主动脉插管将7只家猪连接到体外循环。用标准主动脉套管插管的三只猪被定义为对照。进行了几种主要的流动和抽吸方案。将不同大小的骨颗粒注入近端主动脉以模拟栓塞。
结果：CardioGard套管显示总栓子取回率为77%。在主动脉操作期间临床使用的低流量方案中，证实了88.45％的比率。气体和固体栓塞通过抽吸消除，正如颈动脉超声所证明的。血液动力学和实验室参数未观察到显着变化。
结论：CardioGard插管与常规的市售主动脉插管一样易于使用，在捕获术中栓塞方面具有相似的安全性和已证实的功效。
