%0 Journal Article
%T Novel emboli protection cannula during cardiac surgery: first animal study.
%A Shani L
%A Cohen O
%A Beckerman Z
%A Nir RR
%A Bolotin G
%J Asian Cardiovasc Thorac Ann
%V 22
%N 1
%D Jan 2014
%M 24585639
暂无%R 10.1177/0218492312467543
%X <B>BACKGROUND: </B>Stroke after open heart surgery is a major cause of morbidity and mortality. Up to 60% of intraoperative cerebral events are caused by emboli generated by manipulations of the aorta during surgery. This is the first animal study evaluating the safety and efficacy of a novel aortic cannula designed to extract solid and gaseous emboli during cardiac surgery.<BR><B>METHODS: </B>Seven domestic pigs were connected to cardiopulmonary bypass using a CardioGard 24F aortic cannula. Three pigs that were cannulated with a standard aortic cannula were defined as controls. Several main flow and suction regimens were carried out. Osseous particles of different sizes were injected into the proximal aorta to simulate emboli.<BR><B>RESULTS: </B>The CardioGard cannula demonstrated an overall emboli retrieval rate of 77%. A rate of 88.45% was demonstrated during the low-flow regimen used clinically during aortic manipulation. Gaseous and solid emboli were eliminated by suction, as demonstrated by epi-carotid ultrasound. No significant changes were observed in hemodynamic and laboratory parameters.<BR><B>CONCLUSIONS: </B>The CardioGard cannula is as simple to use as a regular commercially available aortic cannula, having a similar safety profile and proven efficacy in capturing intraoperative emboli.