自身免疫调节因子 (AIRE) 蛋白的生物物理和生化特性。
关键词: 100-kDa speckled protein 110-kDa speckled protein 140-kDa speckled protein AIRE APECED APS1 Autoimmune polyendocrinopathies CARD CBP CIITA CREB-binding protein ChIP DAXX Deaf1 EMSA GST Gfp HEK293 HSR ING2 MHCII MHCII transactivator MM/PBSA MS Molecular Mechanics/Poisson–Boltzmann Surface Area NB NLS NMR NucP41/75 P-TEFb PGE PHD PIAS1 PK PML PRR PTM Post-translational protein processing Protein conformation RING RNA-PolII RNA-polymerase II SAND STAT Self-tolerance Sp100 Sp100, AIRE, NucP41/75 and Deaf1 Sp110 Sp140 Transcription factors TsAg aa amino acid(s) autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy autoimmune polyglandular syndrome type 1 autoimmune regulator caspase-recruitment domain chromatin immunoprecipitation class-II major histocompatibility complex coIP coimmunoprecipitation death-associated protein 6 deformed epidermal autoregulatory factor 1 electrophoretic mobility shift assay glutathione-S-transferase green fluorescent protein homogeneously-staining region human-embryonic-kidney epithelial-cell line 293 inhibitor of growth 2 mTEC mass spectrometry medullary thymic epithelial cell nuclear body nuclear localization signal nuclear magnetic resonance nuclear phosphoprotein 41/75 plant homeodomain positive transcription elongation factor b post-translational modification proline-rich region promiscuous gene expression promyelocytic leukemia protein inhibitor of activated STAT 1 protein kinase really-interesting new gene signal transducer and activator of transcription tissue-specific antigen
Mesh : Animals Gene Expression Regulation Humans Models, Molecular Mutation Protein Binding Protein Multimerization Protein Structure, Tertiary Transcription Factors / chemistry genetics metabolism AIRE Protein
来 源: DOI:10.1016/j.bbadis.2013.11.020